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Diet, Gene Expression, and Apbptosis: Clues to Cancer Prevention?

机译:饮食,基因表达和开胃化:癌症预防的线索?

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The development of cancer results from the interplay between genetic factors and the environment, and dietary factors have been identified as modulators of almost every step in the process. The complexity of this interplay between genetic factors and the nutritional environment is summarized in Fig. 1. In its initial stage, the development of a tumor requires genetic damage, caused either by endogenous processes or by exogenous compounds that produce mutations or even gene deletions.Free radicals are one of the endogenous mediators of oxidative DNA damage and mutations. They are produced by normal oxidative metabolism in cells, but their production is increased under pathologic conditions such as inflammation. The hydroxyl radical is considered to be the ultimate radical species responsible for DNA damage.
机译:癌症的发展来自遗传因素与环境之间的相互作用,以及膳食因素已被确定为几乎每一步的调节剂。在图4中总结了遗传因子和营养环境之间这种相互作用的复杂性。在其初始阶段,肿瘤的发育需要遗传损伤,由内源过程或产生突变的外源化合物或甚至基因缺失。自由基是氧化DNA损伤和突变的内源性介质之一。它们是通过细胞中正常的氧化代谢产生的,但它们的产量在炎症如病理条件下增加。羟基自由基被认为是负责DNA损伤的最终自由基物质。

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