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Oxidatlve Stress: Antioxidants in Degenerative Neurologic and Ophthalmologic Diseases

机译:oxidatlve应激:退化神经系统和眼科疾病中的抗氧化剂

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Reactive oxygen species, also called prooxidants, are produced physiologically during normal metabolic reactions in the aerobic organism. However, when they are produced in excessive amounts and are not sufficiently detoxified, the steady state balance between prooxidants and antioxidants may be disrupted. An imbalance in favor of the prooxidants and against the antioxidants then occurs. This has been called "ox-idative stress" (1-3), and can lead to damage affecting all types of biologic molecules, including DNA, lipids, protein, and carbohydrates. Oxidative stress is thus involved in processes such as mutagenesis, carcinogenesis, cellular dysfunction, and tissue degeneration.
机译:在有氧生物体中正常代谢反应期间,在生理学上产生反应性氧物种,也称为寄射剂。然而,当它们以过量的量产生并且没有充分解毒时,寄生体和抗氧化剂之间的稳态平衡可能被破坏。然后发生有利于寄生剂和抗氧化剂的不平衡。这已被称为“ox-itepend应激”(1-3),可以导致影响所有类型的生物分子,包括DNA,脂质,蛋白质和碳水化合物的损伤。因此,氧化应激参与诸如诱变,致癌,细胞功能障碍和组织变性的方法。

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