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首页> 外文会议>International Conference on Food Factors >Fibrinolytic and anti-thrombotic effect of NKCP, the protein layer from Bacillus subtilis (natto)
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Fibrinolytic and anti-thrombotic effect of NKCP, the protein layer from Bacillus subtilis (natto)

机译：NKCP的纤维蛋白溶解和抗血栓形成效应，来自枯草芽孢杆菌（纳豆）的蛋白质层

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NKCP is the completely refined protein layer from cultured Bacillus subtilis (natto) and is supplied in tablet form. It lacks the distinctive fermented odor and bacteria associated with fresh natto. Almost all vitamin K is removed during the manufacturing process. The main component of NKCP is the active fragment of Bacillopeptidase F, which is a serine protease secreted by Bacillus subtilis. In in vivo studies, NKCP shows fibrinolytic and amidolytic activity on plasmin specific synthetic substrate.Daily oral administration of NKCP in 28 volunteers for two weeks and then in 23 volunteers for several months, was examined. The fibrinolytic effect was demonstrated by a shortened euglobulin lysis time in both trials. Furthermore, we observed an improvement in shoulder stiffness. These results suggest that the oral administration of NKCP can be expected to have a fibrinolytic effect and cause positive changes in local blood flow. Further investigations may demonstrate NKCP to be useful in the prevention of thrombosis.
机译：NKCP是来自培养的枯草芽孢杆菌（纳豆）的完全精制的蛋白质层，并以片剂形式供应。它缺乏与新鲜纳豆相关的独特发酵的气味和细菌。在制造过程中几乎所有维生素K都被除去。 NKCP的主要成分是Bacillopeptivease F的活性片段，其是由枯草芽孢杆菌分泌的丝氨酸蛋白酶。在体内研究中，NKCP在纤溶酶特异性合成底物上显示纤维蛋白溶解和酰胺溶解活性。在28例志愿者中，NKCP的NKCP施用两周，然后在23例志愿者进行了几个月的研究。在两种试验中，通过缩短的eGulobloblin裂解时间证明了纤维蛋白溶解效果。此外，我们观察到肩刚度的改善。这些结果表明，NKCP的口服给药可以预期具有纤维蛋白溶解作用并导致局部血流的阳性变化。进一步的调查可以证明NKCP可用于预防血栓形成。

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