Hypoxia and Apoptosis with bcl-2 Expression in Urothelial Bladder Carcinoma

机译：尿道膀胱癌中的Bcl-2表达缺氧和细胞凋亡

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Hypoxia-inducible factor 1 alpha (HIF-loc) plays an initial role in angiogenesis and pleiotropic response observed under hypoxia. Using immunohistochemistry we investigated hypoxia, apoptosis and bcl-2 immunoreactivity in 93 urothelial cancer (UC) specimens of the bladder. A close association between HIF-loc overexpression and poor differentiation, and a significant relationship between apoptotis and the tumor grade and stage of UCs were observed. A significant correlation between HIF-loc accumulation and apoptotic rate was also detected. As a transcriptional factor, HIF-lot transactivates genes involved in metabolism, angiogenesis and proliferation-processes that are accompanied by frequent apoptosis, probably because of the genetic instability of the aggressive tumors, leading to the production of cells undergoing apoptotic cell death.

机译：缺氧诱导因子1α（HIF-LOC）在缺氧下观察到的血管生成和抗血液辐射反应中的初始作用。使用免疫组织化学我们在膀胱93尿路上皮癌（UC）标本中研究了缺氧，细胞凋亡和Bcl-2免疫反应性。观察到HIF-LEC过表达和分化差的紧密关系，以及间隙与UCS的肿瘤级和肿瘤等级之间的显着关系。还检测到HIF-LOC积累与凋亡率之间的显着相关性。作为转录因子，HIF批次转移伴随着代谢，血管生成和增殖过程中的基因，伴随着频繁的细胞凋亡，可能是因为侵袭性肿瘤的遗传不稳定，导致经历凋亡细胞死亡的细胞的产生。

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《International conference on tumor microenvironment》|2004年||共6页
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V.E. Theodoropoulos; A.C. Lazaris; I. Gerzelis; I. Ghikonti; A. Tsigka; V. Tsoukala; F. Sofras; E. Patsouris and I. Kastriotis;
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中图分类肿瘤病理学、病因学;
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1. The effect of antisense Bcl-2 oligonucleotides on Bcl-2 protein expression and apoptosis in human bladder transitional cell carcinoma. [J] . Duggan BJ, Maxwell P, Kelly JD, The Journal of Urology . 2001,第3期

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2. Ki67 and Bcl-2 immunoexpression in primitive urothelial bladder carcinoma [J] . M. Enache, Cristiana Simionescu, Luana Corina Lascu Romanian Journal of Morphology and Embryology . 2012,第3期

机译：原发性尿路上皮癌中Ki67和Bcl-2的免疫表达
3. Evaluation of hypoxia-inducible factor 1alpha overexpression as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma. [J] . Theodoropoulos VE, Lazaris AC, Kastriotis I, BJU international . 2005,第3期

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4. Hypoxia and Apoptosis with bcl-2 Expression in Urothelial Bladder Carcinoma [C] . V.E. Theodoropoulos, A.C. Lazaris, I. Gerzelis, International conference on tumor microenvironment . 2004

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5. Immunologic aspects of urothelial carcinomas of the urinary bladder: The role of T cell costimulation and coinhibition. [D] . Inman, Brant Allen. 2011

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6. Knockdown of fibrous sheath interacting protein 1 expression reduces bladder urothelial carcinoma cell proliferation and induces apoptosis via inhibition of the PI3K/AKT pathway [O] . Ming Sun, Zhaofu Chen, Shutao Tan, 2018

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7. Apoptosis in Transitional Cell Carcinoma of Bladder and its Relation to Proliferation and Expression of P53 and Bcl-2 [O] . 2015

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Hypoxia and Apoptosis with bcl-2 Expression in Urothelial Bladder Carcinoma

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