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首页> 外文会议>Food and Agriculture Organization of the United Nations-International Epizootic Office-Australia/Brazil-International Atomic Energy Agency Consultative Group on Contagious Bovine Pleuropneumonia >Molecular mechanisms of virulence and antigenicity of Mycoplasma mycoides subsp. mycoides SC: Conclusions for prevention and control of CBPP
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Molecular mechanisms of virulence and antigenicity of Mycoplasma mycoides subsp. mycoides SC: Conclusions for prevention and control of CBPP

机译：毒力和支原体霉菌菌毒力和抗原性的分子机制。 Mycoides SC：用于预防和控制CBPP的结论

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摘要

Mycoplasma mycoides subspecies mycoides SC (Mmm SC), the etioiogical agent of contagious bovine pleuropneumonia (CBPP), is a highly virulent Mycoplasma species, In spite of the fact that this pathogen has been identified more than 100 years ago, its molecular mechanisms of pathogenicity and its virulence factors are still poorly known. However, in order to design novel rational diagnostic tools and safe and efficient vaccines to control this disease, it is essential to know the mechanisms of pathogenicity of this organism, So far no particular primary virulence factors such as toxins or invasins have been evidenced in Mmm SC, nor have primary virulence genes been among those Mycoplasma species whose full genomic sequences had been determined. This might be due to the extremely small genome of mycoplasmas leading them to a drastic economization in genetic resources which are reduced to essential functions of life (Razin et al., 1998), Our current studies indicate that mycoplasmas seem to have adopted efficient structural surface antigens and basic metabolic pathway functions as virulence effectors to cause a disease.
机译：Mycoplasma mycoides亚种Mycoides sc（mmm sc），传染牛胸膜肺炎（cbpp）的肠杆菌剂是一种高毒性的支原体物种，尽管该病原体已被识别超过100年前，其致病性的分子机制它的毒力因素仍然是众所周知的。然而，为了设计新的合理诊断工具和安全有效的疫苗来控制这种疾病，必须了解这种生物的致病性机制，到目前为止没有特别的毒力因子，例如毒素或侵袭性的主要毒力因子已经在毫米中证明了毒素或侵袭性SC，也没有初级毒力基因是那些已经确定了全基因组序列的支原体物种中。这可能是由于支原体的极小基因组，导致他们在遗传资源中急剧节约，这减少了生命的基本功能（Razin等，1998），我们目前的研究表明，支原体似乎采用了高效的结构表面抗原和基本代谢途径用作引起疾病的毒力效应。

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