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首页> 外文会议>Asia Pacific Congress of Allergology and Clinical Immunology >The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation - A Study Using the HDC Knockout Mouse -
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The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation - A Study Using the HDC Knockout Mouse -

机译：组胺在过敏气道炎症中戈尔特细胞增生中的作用 - 一种使用HDC敲除鼠标的研究 -

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摘要

The mechanism of goblet cell hyperplasia in the airway of asthma is not completely understood. We examined the role of histamine in goblet cell hyperplasia using histamine deficient mice (HDC-KO mouse). Wild and HDC-KO C57BL/6 mice were sensitized with ovalbumin (OVA). After two-week exposure to OVA, lungs were excised and goblet cell hyperplasia was evaluated histologically. The mRNA level of Gob-5 was greatly increased in KO mice compared to wild mice. The ratio of the goblet cells in the airway epithelium was markedly increased in KO-mice compared to wild mice. These data suggested that histamine is involved in goblet cell hyperplasia of airway epithelium in allergic airway inflammation.
机译：哮喘气道中脚酚细胞增生的机制尚未完全理解。我们研究了使用组胺缺陷小鼠（HDC-KO小鼠）中甲酚细胞增生中组胺的作用。野生和HDC-KO C57BL / 6小鼠用卵烧（OVA）敏化。在向OVA暴露两周后，切除肺部，在组织学上评估脚螺细胞增生。与野生小鼠相比，KO小鼠中GOB-5的mRNA水平大大增加。与野生小鼠相比，KO-小鼠中，气道上皮中的杯状细胞的比例显着增加。这些数据表明，组胺参与了过敏气道炎症的气道上皮的脚螺细胞增生。

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