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Peripheral Sensitisation in Patients with OA and RA

机译：OA和RA患者的外周致敏

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Proinflammatory nociceptive molecules such as serotonin, ATP, bradyki-nin and substance P are involved in the peripheral sensitisation in patients with symptomatic osteoarthritis (OA) and rheumatoid arthritis (RA) in respect to the interaction with polymodale peripheral receptors such as P2X receptors and TRPV1 receptors, which become sensitised and lower their threshold with the result that the input to the central nervous system increases. Our group could show some of these receptors, as well as the DREAM gene, in synovial fibroblasts from osteoarthritic and rheumatoid arthritic joints, which was, until now, unknown. These molecules might become important in terms of therapeutical approaches to ameliorate the situation of chronic pain patients.
机译：诸如血清素，ATP，Bradyki-nin和物质P患者的促炎伤害分子如症状性骨关节炎（OA）和类风湿性关节炎（RA）的外周致敏，就与P2X受体等P2X受体和TRPV1相互作用受体，其变得敏感并降低其阈值，结果是对中枢神经系统的输入增加。我们的小组可以展示一些这些受体以及梦想基因，从骨关节炎和类风湿性关节关节中的滑膜成纤维细胞中，直到现在，迄今为止未知。这些分子在治疗慢性疼痛患者的情况方面可能变得重要。

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