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首页> 外文会议>International Symposium on Atherosclerosis >Cloning, tissue distribution and function of ABCA transporters
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Cloning, tissue distribution and function of ABCA transporters

机译：ABCA转运蛋白的克隆，组织分布和功能

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We cloned the full-length cDNA of ABCA2 -ABCA2 is expressed predominantly in the oligodendrocytes in the biain, and onset of ABCA2 expression in the oligodendrocytes coincides with the appearance of thick myelin basic protein (MBP)-immunolabeled myelin segments Oligodendrocytes produce the lamellar structure myelin, which is composed of phospholipids and specific myelin proteins.We also cloned ABCA3 from human lung and found that ABCA3 is expressed predominantly at the limiting membrane of the lamellar bodies of alveolar type II cells in human lung Pulmonary surfactant, composed mainly of phospholipids and specific surfactant proteins, is stored as lamellar bodies before exocytosis into the alveolar space.These data suggest that ABCA2 and ABC A3 are involved in membrane transport of substrates such as the lipids that are closely linked to myelin and surfactant formation processes.
机译：我们克隆了ABCA2 -ABCA2的全长cDNA主要在脱蛋白中的少突胶质细胞中表达，并且在少霉细胞中的ABCA2表达的发作与厚髓鞘碱性蛋白（MBP）的外观相一致--Immunolabeled髓鞘寡核细胞寡核苷酸产生层状蛋白酶由磷脂和特异性髓鞘组成的髓鞘。我们也克隆了来自人肺的ABCA3，发现ABCA3主要在人肺表面活性剂中的肺泡型II细胞的层状膜的限制膜上表达，主要由磷脂组成和特异性表面活性剂蛋白，在胞尿精中储存到肺泡空间之前的层状体。这些数据表明ABCA2和ABC A3涉及诸如与髓鞘和表面活性剂形成过程密切相关的脂质的膜的膜传输。

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