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首页> 外文会议>Conference on lasers in surgery: Advanced characterization, therapeutics, and systems >Noncoherent light for PDT of spontaneous animal tumors
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Noncoherent light for PDT of spontaneous animal tumors

机译：用于自发性动物肿瘤的PDT的非组织光

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Cultured 9L cells were incubated with graded doses of pheophorbide-a-hexyl ether (HPPH) and exposed to 665 nm red light from either a noncoherent light source or a KTP-pumped dye laser. Cell death was observed after irradiation using either light source, with the noncoherent light being most effective at the highest HPPH concentrations. To determing the practicality of using the noncoherent light source for clinical PDT, dogs and cats with spontaneous tumors were injected intravenously with 0.15 mg/kg HPPH one hour before their tumors were irradiated with 665 nm noncoherent light (50 mW cm~(-2), 100 J cm~(-2)). Of the 9 tumors treated, 8 complete responses were observed, all of which occurred in animals with squamous cell carcinoma. After 68 weeks of follow up, the median initial disease free interval had not been reached. These data support the use of noncoherent light sources for PDT of spontaneous tumors in animals, representing a cost-effective alternative to medical lasers in both veterinary and human dermatology and oncology.
机译：将培养的9L细胞与分级剂量的噬冰蛋白-A-己醚（HPPH）一起温育，并从非相干光源或KTP泵浦染料激光暴露于665nm红光。使用光源照射后观察细胞死亡，非相干光在最高HPPH浓度下最有效。为了确定使用临床PDT的非相干光源的实用性，在用665nm非相干光（50mWcm〜（-2）中静脉注射0.15mg / kg HPPH，静脉内注射自发肿瘤的狗和具有自发肿瘤的猫。 ，100 j cm〜（-2））。在治疗的9种肿瘤中，观察到8种完全反应，所有这些响应都发生在具有鳞状细胞癌的动物中。随访68周后，尚未达到中位的初始疾病间隔。这些数据支持在动物中使用用于PDT的非组织光源，代表兽医和人类皮肤病学和肿瘤学中的医用激光器的经济有效替代品。

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