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Developing an animal model for the study of fusion using RF energy

机译：利用射频能源开发融合研究的动物模型

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BACKGROUND: A reliable method of blood vessel fusion or sealing has been developed. This method works by applying RF energy and pressure to the walls of a vessel to create a seal. Several methods are used to evaluate the quality of the seal. The main criteria include pressurizing the vessel to failure and using histology to evaluate the integrity of the seal. Burst pressure testing quantifies seal quality, and histology stains reveal the fusion quality of the seal. In addition, histology can show the comparison of morphology and degree of fusion in different tissues. The purpose of the study was to develop an animal model for the human coronary artery bypass graft (CABG) and saphenous vein harvest procedure. METHODS: Experiments were conducted on ovine femoral veins and porcine epigastric veins to demonstrate, through histology and burst testing, the quality of seals. This research details the process of developing an animal model that best approximates the traditional harvest of the saphenous vein for the CABG procedure. RESULTS: Through a series of acute and chronic labs, this research developed a procedure on the ovine model to simulate a peripheral vascular procedure, similar to a femoral bypass. This peripheral vascular procedure on the ovine uses the femoral vein as an interpositional graft onto the femoral artery. In addition, this research identified a second animal model on which to evaluate the healing effects of sealed side branches in a cardiovascular procedure. This research path used the porcine model for a CABG procedure. The epigastric vein was harvested as an autologous vein graft for bypassing the LAD on the pig heart.
机译：背景：已经开发了一种可靠的血管融合或密封方法。该方法通过将RF能量和压力施加到容器的壁上以产生密封。使用几种方法来评估密封的质量。主要标准包括将血管加压到失败并使用组织学评估密封的完整性。突发压力测试量化密封质量，组织学污渍揭示了密封件的熔化质量。此外，组织学可以显示不同组织中的形态和融合程度的比较。该研究的目的是为人类冠状动脉旁路移植物（CABG）和隐静脉收获程序开发动物模型。方法：通过组织学和爆发测试，在绵羊股骨静脉和猪上血管静脉上进行实验，通过组织学和突发测试，密封件的质量。该研究详细介绍了开发动物模型的过程，该动物模型最靠近传统的静脉静脉对CABG程序的过程。结果：通过一系列急性和慢性实验室，该研究在绵羊模型上开发了一种程序，以模拟外周血管手术，类似于股骨旁路。羊膜上的这种外周血管血管手术使用股骨静脉作为股动脉上的介入移植物。此外，该研究确定了第二种动物模型，用于评估密封侧分支在心血管过程中的愈合效果。该研究路径使用了CABG程序的猪模型。被收获的ePigastric静脉作为自体静脉移植物，用于绕过猪心脏上的小伙子。

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