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首页> 外文会议>International AIDS Conference >HIV Disease and Disseminated Subcutaneous Lipomatosis. Another Untoward Effect of Highly Active Antiretroviral Therapy, Possibly Related to Dysmetabolism?
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HIV Disease and Disseminated Subcutaneous Lipomatosis. Another Untoward Effect of Highly Active Antiretroviral Therapy, Possibly Related to Dysmetabolism?

机译：艾滋病毒疾病和散发皮下脂质瘤。另一种不知情的抗逆转录病毒治疗的效果，可能与携带多样性蛋白质有关吗？

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摘要

The so-called "lipodystrophy" syndrome includes a broad range of changes of body habitus occurring in HIV-infected patients, in the great majority of cases when highly active antiretroviral therapy (HAART) is of concern. While peripheral lipoatrophy seems to depend mainly on mitochondrial abnormalities prompted by nucleoside reverse transcriptase inhibitors, visceral or abdominal fat accumulation is attributed to a predominant effect of HIV protease inhibitors. However, the majority of patients treated with combination HAART regimen tend to suffer from a mixed form of peripheral lipoatrophy and trunk fat increase (central obesity). In this overlapping scenario, localized lipid accumulations have been rarely described in the form of a diffuse, multiple subcutaneous lipomatosis. This "new" syndrome has been recently observed in 11 patients followed at our reference centre (all accompanied by dysmetabolism and some features of the lipodystrophy syndrome), and is now discussed on the ground of the most recent literature evidences.
机译：所谓的“脂肪蓄水池”综合征包括在艾滋病毒感染患者中发生的身体栖息地的广泛变化，在大多数情况下，当高度活跃的抗逆转录病毒治疗（HAART）是关注的。虽然外周脂质养老液主要依赖于核苷逆转录酶抑制剂的线粒体异常，但内脏或腹部脂肪积累归因于HIV蛋白酶抑制剂的主要效果。然而，用组合HAART方案治疗的大多数患者往往患有混合形式的外周脂质养殖和躯干脂肪增加（中央肥胖）。在这种重叠场景中，局部化脂质累积以弥漫性，多次皮下脂质瘤症的形式很少描述。在11名患者中最近观察到这种“新”综合征在我们的参考中心（伴随着软体蛋白综合征的一些特征），现在以最近的文献证据的理由讨论。

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