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首页> 外文会议>International Conference on Multi-Material Micro Manufacture >Novel characterisation methods of microneedles manufactured by micro-injection moulding
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Novel characterisation methods of microneedles manufactured by micro-injection moulding

机译：微注射成型制造微针的新型表征方法

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There are wide variety of methods of manufacture of microneedles (MN) and a diversity of MN designs and application methods. In this study we develop new routes for MN manufacture primarily using micro-injection moulding (μIM) processes with a range of high performance engineering thermoplastics with high volume outputs. To enable optimal characterisation and to assess the performance of these MNs a greater understanding of its penetration behaviour is required. The forces required for the mechanical failure, contact stiffness, creep behaviour & as well as mechanisms for MN penetration into porcine skin were studied. The scale of micro moulded products causes problems when considering assessment of dimensional properties, so Confocal Laser Microscopy (CLM) and Atomic Force Microscopy (AFM) were used to measure the tip radius and height of MN arrays. The failure forces were found to be much higher than forces necessary for skin penetration. Images captured during the failure force measurements showed that bending was the most common form of failure. The output of this findings will provide proof of concept level development and understanding of mechanisms of MN needle penetration and failure, facilitating design improvements for μIM polymeric MNs.
机译：各种各样的微针（Mn）制造方法和MN设计和应用方法的多样性。在这项研究中，我们主要使用微注射成型（μIM）工艺为MN制造的新路线开发了具有高容量输出的高性能工程热塑性塑料的微注射成型（μIM）工艺。为了实现最佳表征并评估这些MNS的性能，需要更大了解其渗透行为。研究了机械故障，接触刚度，蠕变行为以及MN渗透到猪皮中的机制所需的力。微模制品的规模在考虑尺寸特性评估时会出现问题，因此共聚焦激光显微镜（CLM）和原子力显微镜（AFM）用于测量Mn阵列的尖端半径和高度。发现失败力远高于皮肤渗透所需的力。在故障强制测量期间捕获的图像显示弯曲是最常见的故障形式。该发现的产出将提供概念水平开发证明和对Mn针穿透和失效机制的理解，促进μIM聚合物MN的设计改进。

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