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首页> 外文会议>International Conference on Natural Products and Molecular Medicine >TRAIL (TNF-Related Apoptosis-Inducing Ligand) Induces Necrosis-Like Cell Death in Tumor Cells at Acidic Extracellular pH
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TRAIL (TNF-Related Apoptosis-Inducing Ligand) Induces Necrosis-Like Cell Death in Tumor Cells at Acidic Extracellular pH

机译：TRAIL（与TNF相关的凋亡诱导配体）在酸性细胞外pH下诱导肿瘤细胞中的坏死状细胞死亡

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How tumor microenvironment, more specifically low extracellular pH (6.5), alters cell response to TNF-related apoptosis-inducing ligand (TRAIL)-based cancer therapy has yet to be determined. The aim of the current work was to test the effect of acidic extracellular pH on TRAIL-induced cell death in human HT29 colon carcinoma and HepG2 hepatocarcinoma cell lines as well as in human primary hepatocytes. We found an increase in TRAIL sensitivity at low extracellular pH, which is partially inhibited by Bcl-2 expression in HT29 cells. At low extracellular pH, TRAIL induced a new form of cell death, sharing necrotic and apoptotic features in tumor cells. By contrast, human primary hepatocytes were resistant to TRAIL-induced cell death even at acidic extracellular pH.
机译：肿瘤微环境如何，更具体地低细胞外pH（6.5），改变对TNF相关的凋亡诱导配体（基于基于TWAT）的癌症治疗的细胞反应。目前工作的目的是测试酸性细胞外pH对人HT29结肠癌和HepG2肝癌细胞系以及人原发性肝细胞的诱导细胞死亡的影响。我们发现低细胞外pH的痕迹敏感性增加，其在HT29细胞中被Bcl-2表达部分抑制。在低细胞外pH值下，TRAIL诱导一种新的细胞死亡形式，分享肿瘤细胞中的坏死和凋亡特征。相比之下，即使在酸性细胞外pH下，人原发性肝细胞也耐抗尾部诱导的细胞死亡。

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