Oxidative Damage in Mitochondrial DNA Is Not Extensive

机译：线粒体DNA中的氧化损伤不是广泛的

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Since 1988 several research groups have reported greater levels of oxidative damage in mitochondrial DNA than in nuclear DNA, while others have suggested that the greater damage in mtDNA might be due to artifactual oxidation. The popular theory that mtDNA is more heavily damaged in vivo than nDNA does not stand on firm ground. Using an improved GC-MS method and pure mtDNA, our analyses revealed that the damage level in mtDNA is not higher, and may be somewhat lower, than that in nDNA.

机译：自1988年以来，几个研究组在线粒体DNA中报告了比核DNA更大水平的氧化损伤，而其他研究群体表明MTDNA的损害可能是由于造成造成的氧化。 MTDNA在体内损坏的流行理论比NDNA更受损坏，不符合坚定的地面。使用改进的GC-MS方法和纯MTDNA，我们的分析显示，MTDNA的损伤水平不高，并且可能比NDNA中的损伤水平略低。

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《Asian Society for Mitochondrial Research and Medicine》|2005年||共11页
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作者
KOK SEONG LIM; KANDIAH JEYASEELAN; MATTHEW WHITEMAN; ANDREW JENNER; BARRY HALLIWELL;
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原文格式 PDF
正文语种
中图分类 R361-532;
关键词
mtDNA; nDNA; oxidative damage; GC-MS; 8-OH guanine;

机译：mtdna;ndna;氧化损伤;GC-MS;8-OH GUILINE;

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专利

1. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress [J] . F. Michael Yakes, Bennett Van Houten Proceedings of the National Academy of Sciences of the United States of America . 1997,第2期

机译：氧化应激后，线粒体DNA损伤比人细胞中的核DNA损伤更为广泛，并且持续时间更长
2. Oxidative Damage in Mitochondrial DNA Is Not Extensive [J] . KOK SEONG LIM, KANDIAH JEYASEELAN, MATTHEW WHITEMAN, Annals of the New York Academy of Sciences . 2005,第May期

机译：线粒体DNA的氧化损伤并不广泛。
3. Mercury-induced cellular damage is associated with enhanced mitochondrial DNA damage, oxidative stress and mitochondrial dysfunction [J] . Rao S. B. S., Das S., Joshi M. B. Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2019,第期

机译：汞诱导的细胞损伤与增强的线粒体DNA损伤，氧化应激和线粒体功能障碍有关
4. Oxidative Damage in Mitochondrial DNA Is Not Extensive [C] . KOK SEONG LIM, KANDIAH JEYASEELAN, MATTHEW WHITEMAN, Asian Society for Mitochondrial Research and Medicine . 2005

机译：线粒体DNA中的氧化损伤不是广泛的
5. Biological consequences of mitochondrial DNA damage and oxidative stress. [D] . Zhang, Haihong. 2006

机译：线粒体DNA损伤和氧化应激的生物学后果。
6. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress [O] . F. Michael Yakes, Bennett Van Houten 1997

机译：氧化应激后线粒体DNA损伤比人细胞中的核DNA损伤更为广泛并且持续时间更长
7. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. [O] . C. Richter, J. W. Park, B. N. Ames 1988

机译：对线粒体和核DNA的正常氧化损伤是广泛的。

Oxidative Damage in Mitochondrial DNA Is Not Extensive

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