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Potential Mechanism of Blood Vessel Protection by Resveratrol, a Component of Red Wine

机译:白藜芦醇血管保护潜在机制,红酒的组成部分

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Resveratrol-mediated heme oxgenase-1 (HO-1) induction has been shown to occur in primary neuronal cultures and has been implicated as having potential neuroprotective action. Further, antioxidant properties of resveratrol have been reported to protect against coronary heart disease. We attempted to examine the HO-1 inducing potency of resveratrol and the regulatory mechanism of its induction in rat aortic smooth muscle cells (RASMC). We showed that resveratrol-induced HO-1 expression was concentration- and time-dependent. The level of HO-1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor-kappa B (NF-κB) inhibitors, but not by mitogen-activated protein kinase (MAPK) inhibitors. Deletion of NF-κB binding sites in the promoter region strongly reduced luciferase activity. Collectively, we suggest that resveratrol-mediated HO-1 expression occurs, at least in part, through the NF-κB pathway.
机译:已显示白藜芦醇介导的血红素氧酶-1(HO-1)诱导在原发性神经元培养物中发生,并且涉及具有潜在的神经保护作用。此外,据报道,白藜芦醇的抗氧化性能以防止冠心病。我们试图检查白藜芦醇的HO-1诱导效力以及其在大鼠主动脉平滑肌细胞(RASMC)中诱导的调节机制。我们表明白藜芦醇诱导的HO-1表达是浓度和时间依赖性的。 HO-1表达及其由白藜芦醇介导的启动子活性的水平官能核因子-Kappa(NF-κB)抑制剂衰减,但不是由丝分裂剂活化的蛋白激酶(MAPK)抑制剂。促进促进剂区域中NF-κB结合位点的缺失强烈降低了荧光素酶活性。统称,我们建议使用白藜芦醇介导的HO-1表达,至少部分地通过NF-κB途径发生。

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