Distribution of charged and uncharged local anesthetics into phospholipid bilayer membrane:Correlation between partition coefficients and anesthetic potency

机译：磷脂双层膜的带电和不带电局部麻醉剂的分布：隔离系数与麻醉效率之间的相关性

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Each of the three states of dipalmitoylphosphatidylcholine (DPPC) bilayer membrane exhibited a different receptivity to anesthetic partitioning, and the partition coefficients of anesthetics in each membrane state were in the order of molecular hydrophobicity. The three phases of DPPC bilayer membranes were more receptive to the uncharged anesthetic than the charged species, and the transfer free energy of anesthetics from the aqueous phase to the different phases of bilayer was well correlated to the local anesthetic potencies.

机译：二硫代酰磷磷苷（DPPC）双层膜中的三种状态中的每一个表现出对麻醉分配的不同接受性，并且每个膜状态中麻醉剂的分配系数为分子疏水性的顺序。 DPPC双层膜的三相更容易受到比带电的物质不带电的麻醉剂，并且从水相中的麻醉剂转移能量与双层不同相的不同阶段与局部麻醉剂良好相关。

著录项

来源
《International Conference on Basic and Systemic Mechanisms of Anesthesia》|2005年||共2页
会议地点
作者
Naho Yamasaki; Kazuhiko Matsuoka; Makoto Nishimoto; Takashi Hata; Hixomu Satake; Hitoshi Matsuk;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类麻醉学;
关键词
Lipid bilayer membrane; Phase; Charged and uncharged local anesthetic; Partition coefficient; Anesthetic potenc;

机译：脂质双层膜;相;充电和局部麻醉;分区系数;麻醉效力;

相似文献

外文文献
中文文献
专利

1. Difference in surface activities between uncharged and charged local anesthetics: correlation with their anesthetic potencies [J] . Hitoshi Matsuki, Kensaku Shimada, Shoji Kaneshina, Colloids and Surfaces, B. Biointerfaces . 1998,第6期

机译：不带电和带电的局部麻醉药之间的表面活性差异：与它们的麻醉效力相关
2. Partitioning of Charged Local Anesthetics into Model Membranes Formed by Cationic Surfactant: Effect of Hydrophobicity of Local Anesthetic Molecules [J] . Hitoshi Matsuki, Shoji Kaneshina, Hiroshi Kamaya, The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 1998,第17期

机译：带电荷的局部麻醉剂分配到阳离子表面活性剂形成的模型膜中：局部麻醉剂分子疏水性的影响
3. Partitioning of Charged Local Anesthetics into Model Membranes Formed by Cationic Surfactant: Effect of Hydrophobicity of Local Anesthetic Molecules [J] . Hitoshi Matsuki, Shoji Kaneshina, Hiroshi Kamaya The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 1998,第17a20期

机译：带电荷的局部麻醉剂分配到阳离子表面活性剂形成的模型膜中：局部麻醉剂分子疏水性的影响
4. Distribution of charged and uncharged local anesthetics into phospholipid bilayer membrane:Correlation between partition coefficients and anesthetic potency [C] . Naho Yamasaki, Kazuhiko Matsuoka, Makoto Nishimoto, International Conference on Basic and Systemic Mechanisms of Anesthesia . 2005

机译：磷脂双层膜的带电和不带电局部麻醉剂的分布：隔离系数与麻醉效率之间的相关性
5. Investigation of the effects of anesthetic compounds on lipid bilayer organization. [D] . Logan-Dinco, Katherine L. 2013

机译：研究麻醉剂对脂质双层组织的影响。
6. Membrane interactivity of charged local anesthetic derivative and stereoselectivity in membrane interaction of local anesthetic enantiomers [O] . Hironori Tsuchiya, Maki Mizogami 2008

机译：带电局麻药衍生物的膜相互作用和局麻药对映体膜相互作用中的立体选择性
7. Partition coefficients of the local anesthetic dibucaine into a lipid bilayer membrane determined with a dibucaine cation sensor [O] . Makoto NISHIMOTO, Kazuhiko MATSUOKA, Kazuhito NAGAYAMA, 2003

机译：局部麻醉剂DiBucaine将局部麻醉剂的分配系数与Dibucaine阳离子传感器测定的脂质双层膜

Distribution of charged and uncharged local anesthetics into phospholipid bilayer membrane:Correlation between partition coefficients and anesthetic potency

摘要

著录项

相似文献

相关主题

期刊订阅