Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes

机译：异丙酚和乙醇对卵脓卵母细胞中P2X4受体对P2X4受体的差异影响

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The current study investigated the effects of propofol on P2X4 receptors expressed in Xenopus oocytes using two-electrode voltage clamp. We also tested the effects of 100 mM ethanol on the same oocytes used to test propofol. Propofol potentiated ATP-gated currents in a concentration dependent manner in P2X4 receptors. In agreement with our previous findings, ethanol inhibited P2X4 receptors. The opposite effects of propofol and ethanol on P2X4 receptor function suggest that these anesthetics act via different sites/mechanisms in P2X receptors as has been suggested for GABA_A and glycine receptors.

机译：目前的研究研究了使用双电极电压夹的Xenopus卵母细胞中表达的P2X4受体对P2X4受体的影响。我们还测试了100mM乙醇在用于测试异丙酚的同一卵母细胞上的效果。异丙酚具有浓度依赖性方式在P2X4受体中具有浓度的ATP门控电流。符合我们以前的发现，乙醇抑制了P2X4受体。异丙酚和乙醇对P2X4受体功能的相反效果表明，这些麻醉剂通过针对GABA_A和甘氨酸受体提出的P2X受体中的不同部位/机制。

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《International Conference on Basic and Systemic Mechanisms of Anesthesia》|2005年||共3页
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D.L. Davies; S.T. Kuo; R.L. Alkan;
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中图分类麻醉学;
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P2X receptor; Two-electrode voltage clamp; Propofol; General anesthetic; Purinergic recepto;

机译：P2x受体;双电极电压夹;异丙酚;全身麻醉;嘌呤能受体;

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1. Effects of propofol on various AMPA-, kainate- and NMDA-selective glutamate receptor channels expressed in Xenopus oocytes. [J] . Yamakura T, Sakimura K, Shimoji K, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1995,第3期

机译：异丙酚对非洲爪蟾卵母细胞中表达的各种AMPA，海藻酸盐和NMDA选择性谷氨酸受体通道的影响。
2. Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. [J] . Cardoso RA, Brozowski SJ, Chavez Noriega-LE, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1999,第2期

机译：乙醇对非洲爪蟾卵母细胞中表达的重组人神经元烟碱乙酰胆碱受体的影响。
3. Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes. [J] . Davies DL, Kochegarov AA, Kuo ST, Neuropharmacology . 2005,第2期

机译：乙醇差异影响非洲爪蟾卵母细胞中表达的ATP门控的P2X（3）和P2X（4）受体亚型。
4. Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes [C] . D.L. Davies, S.T. Kuo, R.L. Alkan International Conference on Basic and Systemic Mechanisms of Anesthesia . 2005

机译：异丙酚和乙醇对卵脓卵母细胞中P2X4受体对P2X4受体的差异影响
5. Effect of ethanol on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes. [D] . Ronald, Kimberly M. 2001

机译：乙醇对非洲爪蟾卵母细胞中表达的突变N-甲基-D-天冬氨酸受体的影响。
6. Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes [O] . D.L. Davies, S.T. Kuo, R.L. Alkana -1

机译：异丙酚和乙醇对非洲爪蟾卵母细胞表达的P2X4受体的差异作用
7. Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes [O] . D.L. Davies, S.T. Kuo, R.L. Alkana 2005

机译：异丙酚和乙醇对卵脓卵母细胞中P2X4受体对P2X4受体的差异影响
8. Characterization of Human Phagocytic Cell Receptors for C5A and PlateletActivating Factor Expressed in Xenopus Oocytes [R] . Murphy, P. M., Gallin, E. K., Tiffany, H. L. 1990

机译：非洲爪蟾卵母细胞中人类吞噬细胞受体C5a和血小板活化因子的表征

Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes

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