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Characteristics of cognitive function in patients with Parkinson's disease: a comparison with healthy subjects

机译：帕金森病患者认知功能的特征：与健康受试者的比较

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The object of the present study was to evaluate the visual event-related potentials (ERPs) and the effects of emotion in patients with Parkinson disease without dementia. Visual ERPs were recorded using an oddball paradigm in 18 patients and 18 age-matched healthy subjects. The P300 amplitude and latency, as well as the subject's reaction time were recorded. There was no difference hi the P300 amplitude between patients and controls when viewing a smiling baby or viewing a crying baby. The P300 amplitude when viewing a smiling baby was smaller than that when viewing a crying baby for the both patients and the healthy controls. The P300 amplitude was significantly larger in the stage 3 group than in the stage 4 group as classified by Hoehn and Yahr. The P300 latency in patients was significantly longer both in group 3 and group 4 patients than that in the healthy controls, in response to both the facial stimuli. These results indicate that patients with Parkinson diseases are likely to have cognitive dysfunction and that ERPs are biological markers useful for the evaluation of patients. These results also suggest that the P300 is influenced by affective facial expressions and that the effects for patients are essentially similar to healthy controls.

机译：本研究的目的是评估与帕金森病患者无痴呆症患者的视觉事件相关的电位（ERP）和情绪的影响。使用18名患者和18名匹配的健康受试者使用奇怪的球员进行记录视觉erps。记录P300的幅度和等待时间以及受试者的反应时间。在观看微笑的宝宝或观看哭泣的婴儿时，患者与控制之间的P300振幅没有区别。观察微笑婴儿时的P300振幅小于两个患者和健康对照的哭泣的婴儿时小。第3阶段P300振幅显着大于由Hoehn和Yahr分类的第4阶段中的阶段4组。患者的P300潜伏期在第3组和第4族患者中显着更长，而不是健康对照的患者，以应对面部刺激。这些结果表明，帕金森疾病的患者可能具有认知功能障碍，并且ERP是对评估患者的生物标志物。这些结果还表明P300受到情感面部表情的影响，患者的效果与健康对照相似。

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《International Evoked Potentials Symposium》|2005年|1st ed|共4页
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K. Morita; H. Shoji; H. Yamamoto; S. Nishiura; Y. Shoji; T. Matuok;
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中图分类中枢神经系统生理学;
关键词
Event-related potentials; P300; Affection; Cognitive function; Parkinson's diseas;

机译：事件相关的潜力;P300;情感;认知功能;帕金森病;

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2. Spontaneous Swallowing during All-Night Sleep in Patients with Parkinson Disease in Comparison with Healthy Control Subjects [J] . Uludag Irem Fatma, Tiftikcioglu Bedile Irem, Ertekin Cumhur Sleep . 2016,第4期

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Characteristics of cognitive function in patients with Parkinson's disease: a comparison with healthy subjects

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