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首页> 外文会议>International Evoked Potentials Symposium >Corticospinal tract and corticobulbar tract dysfunction in ALS: combined study using transcranial magnetic stimulation and diffusion tensor tractography
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Corticospinal tract and corticobulbar tract dysfunction in ALS: combined study using transcranial magnetic stimulation and diffusion tensor tractography

机译：als的皮质脊髓椎间盘和皮质筋箱功能障碍：组合研究使用经颅磁刺激和扩散张量牵引

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We evaluate the degeneration of the corticospinal tract (CST) and the corticobulbar tract (CBT) separately in amyotrophic lateral sclerosis (ALS) patients by tract-specific fractional anisotropy (FA) measurement using diffusion tensor tractography (DTT). Thirty patients with ALS [11 bulbar-onset patients (ALS-B) and 19 limb-onset (ALS-L)] and 17 healthy age-matched controls were recruited. A diffusion tensor echo-planar image with 13 axes was obtained using 1.5-T MR imager. DTT of the corticospinal tract (DTT-CST) and the corticobulbar tract (DTT-CBT) were projected from a seed at the posterior limb of the internal capsule to a target at the superior precentral gyms (DTT-CST) or at the inferior precentral gyrus (DTT-CBT). FA was calculated at serniautomati-cally placed regions-of-interest (ROIs) and averaged in each tract. We measured central motor conduction time (CMCT) and cortical-brainstem conduction time (CTX-BS CT) recorded from the first dorsal interosseous (FDI) muscle. FA of DTT-CST and DTT-CBT of the patients were significantly reduced compared with those of the controls. FA of DTT-CBT was significantly lower in ALS-B than in ALS-L. CMCT and CTX-BS CT showed a significant negative correlation with the FA of DTT-CST, but not with DTT-CBT. DTT is a feasible method to quantitate individual descending motor tract damage in ALS.
机译：通过使用扩散张量牵引牵引（DTT），通过分散的分数各向异性（FA）测量，在肌萎缩侧链（ALS）患者中分别评估皮质椎间盘（CST）和皮质筋的变性（CBT）。招募了30例ALS [11碎片患者（ALS-B）和19只肢体发作（ALS-L）]和17例健康年龄匹配对照。使用1.5-T MR Imager获得具有13轴的扩散张转向平面图像。皮质脊髓椎间盘（DTT-CST）和皮质筋（DTT-CBT）的DTT从内部胶囊后肢的种子投射到优质前列体育体（DTT-CST）或处于下前列的靶gyrus（DTT-CBT）。 FA在Serniautomati-Cally放置的兴趣区（ROI）下计算并在每个道路中平均。我们测量了从第一背侧孔（FDI）肌肉记录的中央电机导通时间（CMCT）和皮质脑干传导时间（CTX-BS CT）。与对照相比，患者的DTT-CST和DTT-CBT的FA显着减少。 Als-B的DTT-CBT的Fa比在Als-L中显着降低。 CMCT和CTX-BS CT与DTT-CST的FA表示显着的负相关，但不具有DTT-CBT。 DTT是一种定量ALS中单个下降机道损伤的可行方法。

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