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MICROGRAVITY AND SIGNALING MOLECULES IN RAT OSTEOBLASTS: DOWNSTREAM OF RECEPTOR TYROSINE KINASE, G-PROTEIN-COUPLED RECEPTOR, AND SMALL GTP-BINDING PROTEINS

机译：大鼠成骨细胞中的微匍匐和信号分子：受体酪氨酸激酶，G蛋白偶联受体和小GTP结合蛋白的下游

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Rat osteoblasts were cultured for 4 and 5 days aboard Space Shuttle and solubilized on board. The mRNA levels of the post-receptor signaling molecules were analyzed by quantitative RT-PCR. The G-protein α subunit Gαq mRNA levels were elevated 3-fold by microgravity. Gαq stimulates PLCβ, and then PKC. PKCδ and PKCv mRNA levels were increased 2- to 5-fold by microgravity. The mRNA levels of SOS and Ras GRF were increased 4 to 5-fold by microgravity, while Ras GAP was not altered. Spaceflight-induced bone loss might be attributed to microgravity modulation of the signaling pathway in osteoblasts.

机译：将大鼠成骨细胞培养4至5天，在航天飞机和溶解的船上溶解。通过定量RT-PCR分析受体后信号传导分子的mRNA水平。 G蛋白α亚基GαQmRNA水平通过微匍匐升高3倍。 GαQ刺激PLCβ，然后是PKC。 PKCδ和PKCV mRNA水平通过微匍匐增加2-5倍。通过微匍匐，SOS和RAS GR的mRNA水平增加4至5倍，而RAS间隙未被改变。诱导的骨质损失可能归因于成骨细胞中信号通路的微匍匐调制。

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《European Symposium on Life Sciences in Space》|2005年||共2页
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Yasuhiro Kumei; Hitoyata Shimokawa; Sadao Morita; Hisako Katano; Hideo Akiyama; Masahiko Hirano; Keiichi Ohya; Clarence F. Sams; Peggy A. Whitson;
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1. Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets [J] . Anna Lecchi, Chiara Cavallini, Clara Lechi?Santonastaso, The biochemical journal . 2006,第1期

机译：在人血小板中血栓烷A2的G蛋白偶联受体下游快速刺激酪氨酸磷酸化信号
2. Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets [J] . Anna Lecchi, Chiara Cavallini, Clara Lechi?Santonastaso, The biochemical journal . 2006,第1期

机译：在人血小板中血栓烷A2的G蛋白偶联受体下游快速刺激酪氨酸磷酸化信号
3. Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A(2) in human platelets [J] . Minuz P, Fumagalli L, Gaino S, The Biochemical Journal . 2006,第1期

机译：人血小板中血栓烷A（2）的G蛋白偶联受体下游酪氨酸磷酸化信号的快速刺激
4. MICROGRAVITY AND SIGNALING MOLECULES IN RAT OSTEOBLASTS: DOWNSTREAM OF RECEPTOR TYROSINE KINASE, G-PROTEIN-COUPLED RECEPTOR, AND SMALL GTP-BINDING PROTEINS [C] . Yasuhiro Kumei, Hitoyata Shimokawa, Sadao Morita, European Symposium on Life Sciences in Space . 2005

机译：大鼠成骨细胞中的微匍匐和信号分子：受体酪氨酸激酶，G蛋白偶联受体和小GTP结合蛋白的下游
5. Regulation of the Galphaq Signaling Pathway by Regulators of G Protein Signaling Proteins, G Protein-Coupled Receptor Kinase 2, and Small Molecule Inhibitors [D] . Thal, David M. 2010

机译：G蛋白信号蛋白，G蛋白偶联的受体激酶2和小分子抑制剂的调节剂对Galphaq信号通路的调节。
6. Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets [O] . Pietro Minuz, Laura Fumagalli, Stefania Gaino, 2006

机译：在人血小板中血栓烷A2的G蛋白偶联受体下游快速刺激酪氨酸磷酸化信号
7. Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets [O] . Minuz, Pietro, Fumagalli, Laura, Gaino, Stefania, 2006

机译：在人血小板中血栓烷A2的G蛋白偶联受体下游快速刺激酪氨酸磷酸化信号

MICROGRAVITY AND SIGNALING MOLECULES IN RAT OSTEOBLASTS: DOWNSTREAM OF RECEPTOR TYROSINE KINASE, G-PROTEIN-COUPLED RECEPTOR, AND SMALL GTP-BINDING PROTEINS

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