• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Symposium on Amyloidosis >INFLUENCE OF INFLAMMATION ON LIPID METABOLISM IN THE PATIENTS WITH RHEUMATOID ARTHRITIS
【24h】

INFLUENCE OF INFLAMMATION ON LIPID METABOLISM IN THE PATIENTS WITH RHEUMATOID ARTHRITIS

机译：炎症对类风湿性关节炎患者脂代谢的影响

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Several lines of evidence show that cardiovascular disease (CVD) is a leading cause of death in patients with rheumatoid arthritis (RA). Standardized mortality ratios for patients with RA dying from CVD are reported to be 1.13 to 5.25 (1, 2). Mortality is not only linked to RA, but strongly linked to RA severity. Total cholesterol (TC) in active RA is reported to be reduced and TC in patients with active RA is reported to be lower than in those with inactive RA (3). Investigators consistently observe reduced high-density lipoprotein cholesterol (HDL-C) levels and frequently find reduced low-density lipoprotein cholesterol (LDL-C) levels in RA patients (3). Thus, the contribution of abnormal lipid metabolism to atherosclerotic change in RA is not clear.Lipoprotein metabolism has been shown to be markedly altered during the inflammatory process in animal models (4) and in human inflammatory diseases (5). Serum amyloid A (SAA) is an apolipoprotein of HDL and a major acute phase protein that can increase to 1000 fold over normal level. During the acute phase response, SAA becomes the major apolipoprotein in HDL particles, and has been shown to change the metabolism and lipid composition of HDL-C (6). Thus SAA could be an important determinant of cholesterol metabolism in chronic inflammatory diseases like RA.The purpose of this study is to reveal influence of inflammation on lipid metabolism in patients with RA.
机译：几种证据表明，心血管疾病（CVD）是类风湿性关节炎（RA）患者死亡的主要原因。将来自CVD死亡的RA患者的标准化死亡率据报道为1.13至5.25（1,2）。死亡率不仅与RA相关联，而且与RA严重程度密切相关。据报道，活性RA中的总胆固醇（TC）减少，据报道，活性RA患者的TC均低于非活性RA（3）的患者。调查人员一直观察降低的高密度脂蛋白胆固醇（HDL-C）水平，并经常在RA患者中发现降低的低密度脂蛋白胆固醇（LDL-C）水平（3）。因此，RA中异常脂质代谢对动脉粥样硬化变化的贡献尚不清楚。在动物模型（4）和人炎症疾病（5）中，已经显示出在炎症过程中显着改变司蛋白代谢。血清淀粉样蛋白A（SAA）是HDL的载脂蛋白和主要急性期蛋白质，可以在正常水平上增加到1000倍。在急性阶段反应期间，SAA成为HDL颗粒中的主要载脂蛋白，并且已被证明改变HDL-C（6）的代谢和脂质组合物。因此，Saa可能是RA等慢性炎症疾病中胆固醇代谢的重要决定因素。本研究的目的是揭示炎症对RA患者脂质代谢的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号