Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films

机译：星形胶质细胞和神经祖细胞对微透明剂膜的生长和分化

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This paper investigates the influence of micropatterned polymers and chemical modification on neural progenitor cell growth and differentiation in co-culture systems with astrocytes. We sought to develop stategies to facilitate nerve regeneration using a synergistic combination of guidance cues, investigating the cellular mechanisms of nerve repair using adult rat hippocampal progenitor cells (AHPCs). Our studies have shown that this synergistic combination of physical, chemical, and biological cues can lead to oriented growth of astrocytes and progenitor cells, can control and accelerate neurite outgrowth and alignment in vitro, and may influence differentiation of progenitor cells.

机译：本文研究了微透明理由聚合物和化学修饰对神经细胞共培养体系中神经祖细胞生长和分化的影响。我们试图利用指导提示的协同组合促进神经再生，研究了使用成年大鼠海马祖细胞（AHPC）的神经修复细胞机制。我们的研究表明，这种协同组合的物理，化学和生物线索可以导致星形胶质细胞和祖细胞的增长，可以控制和加速神经突的过度和体外对准，并且可能影响祖细胞的分化。

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《Growth Factor and Signal Transduction Conference》|2005年||共4页
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JENNIFER B. RECKNOR; D. S. SAKAGUCHI; S. K. MALLAPRAGADA;
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中图分类 Q24-532;
关键词
Schwann cell; neural progenitor cell; micropatterning; photolithography; laminin; nerve regeneration;

机译：Schwann细胞;神经祖细胞;微图案;光刻;LAMININ;神经再生;

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专利

1. Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films [J] . JENNIFER B. RECKNOR, D. S. SAKAGUCHI, S. K. MALLAPRAGADA Annals of the New York Academy of Sciences . 2005,第May期

机译：微图案化聚合物膜上星形胶质细胞和神经祖细胞的生长和分化
2. Directed growth and selective differentiation of neural progenitor cells on micropatterned polymer substrates [J] . Recknor JB, Sakaguchi DS, Mallapragada SK Biomaterials . 2006,第22期

机译：在微图案化聚合物基质上神经祖细胞的定向生长和选择性分化
3. A mathematical model for selective differentiation of neural progenitor cells on micropatterned polymer substrates [J] . Howk C.L., Levine H.A., Smiley M.W., Mathematical Biosciences: An International Journal . 2012,第2期

机译：在微图案化聚合物基质上选择性分化神经祖细胞的数学模型
4. Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films [C] . JENNIFER B. RECKNOR, D. S. SAKAGUCHI, S. K. MALLAPRAGADA Growth Factor and Signal Transduction Conference . 2005

机译：星形胶质细胞和神经祖细胞对微透明剂膜的生长和分化
5. A mathematical model for IL6-induced differentiation of neural progenitor cells on a micropatterned polymer substrate. [D] . Howk, Cory Lee. 2010

机译：IL6诱导的微模式聚合物基质上神经祖细胞分化的数学模型。
6. Soluble factors from neocortical astrocytes enhance neuronal differentiation of neural progenitor cells from adult rat hippocampus on micropatterned polymer substrates [O] . Jisun Oh, Jennifer B. Recknor, Justin C. Recknor, -1

机译：来自Neocortical星形胶质细胞的可溶因子增强了在微型解聚基材上从成年大鼠海马中神经祖细胞的神经元分化
7. Soluble factors from neocortical astrocytes enhance neuronal differentiation of neural progenitor cells from adult rat hippocampus on micropatterned polymer substrates [O] . Oh, Jisun, Recknor, Jennifer B., Recknor, Justin C., 2009

机译：来自新皮层星形胶质细胞的可溶性因子增强了成年大鼠海马神经祖细胞在微图案化聚合物底物上的神经元分化

Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films

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