A Theoretical Study of Hypothalamo-Pituitary-Adrenocortical Axis Dynamics

机译：下丘脑 - 垂体 - 肾上腺皮质轴动力学的理论研究

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Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the system's response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system.

机译：下丘脑 - 垂体 - 肾上腺皮质（HPA）轴本身是否产生振荡？普遍认为，对这个问题的肯定答案是假设的，因为观察到其激素的常规节律。我们提供了对此模式的起源的另一个合理的解释：HPA只是回应外在的起搏器。构建了定性数学模型，其中等式中的所有术语都是物理化学上可解释的。线性稳定性分析表明该系统不会产生振荡。计算机仿真产生振荡，即系统对外部脉冲激活器的响应，这意味着观察到的图案不必是该系统的内在性质。

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《International Biophysics Symposium》|2005年||共3页
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DANKA SAVI?; SMILJANA JELI?;
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中图分类 Q42-532;
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hypothalamo-pituitary-adrenocortical (HPA) axis; circadian rhythm; nonlinear dynamics; stability analysis;

机译：下丘脑 - 垂体 - 肾上腺皮质（HPA）轴;昼夜节律;非线性动力学;稳定性分析;

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A Theoretical Study of Hypothalamo-Pituitary-Adrenocortical Axis Dynamics

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