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首页> 外文会议>International Colloquium on Paratuberculosis >Antigens encoded by the dormancy regulon of Mycobacterium tuberculosis are preferentially recognized by T cells from individuals with latent infection
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Antigens encoded by the dormancy regulon of Mycobacterium tuberculosis are preferentially recognized by T cells from individuals with latent infection

机译：由分枝杆菌的休眠调节件编码的抗原优先由来自潜在感染的个体的T细胞识别

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Recently, the so-called dormancy regulon of Mycobacterium tuberculosis was identified. Comprised of 48 genes, protein expression is noted in vitro during hypoxia and low-dose nitric oxide stimulation. Tubercle bacilli are thought to encounter these conditions in vivo during the onset of immune responses and during subsequent persistence in immune competent hosts. In this study, human immune responses to the 25 most strongly induced dormancy regulon-encoded proteins or candidate latency antigens were assessed, using M. tuberculosis specific T cell lines and peripheral blood mononuclear cells (PBMC) from M. tuberculosis infected persons, including tuberculosis (TB) patients and latently infected individuals, as well as uninfected controls. Nineteen of the 25 tested antigens were recognized by PBMC from M. tuberculosis infected individuals, which demonstrates that the dormancy regulon is indeed expressed during natural M. tuberculosis infection in humans. Interestingly, IFN-gamma production in response to the entire group of latency antigens was significantly higher in latently infected individuals than in TB patients (P < .01). In particular, four antigens were able to induce strong IFN- gamma responses in latently infected individuals. Overall, latency antigens are preferentially recognized by T cells from individuals with latent M. tuberculosis infection suggesting that immune responses against these antigens contribute to controlling latent infection.
机译：近日，结核分枝杆菌的所谓的休眠调节子被确定。由48个基因，蛋白质表达在体外缺氧和低剂量的一氧化氮刺激期间注意到。结核菌被认为是免疫反应的发病过程中和免疫能力的宿主后续持续过程中遇到体内这些条件。在这项研究中，给25个最强烈诱导休眠调节子编码的蛋白质或候选延迟抗原的人免疫应答进行了评估，使用的结核分枝杆菌特异性T细胞系和外周血单核细胞（PBMC）从结核分枝杆菌感染的人，包括肺结核（TB）病人和潜伏感染的个体，以及未感染的对照。 25个测试抗原的19例外周血单个核细胞来自结核分枝杆菌感染的个体，这表明休眠调节子天然结核分枝杆菌感染人类的​​过程中确实表现的认可。有趣的是，IFN-γ生成响应于潜在抗原的整个组在潜伏感染个体显著高于结核病患者（P <0.01）。特别是，四种抗原能够诱发潜伏感染的个体强IFN-伽玛响应。总体而言，潜在抗原优先被T细胞与潜伏结核分枝杆菌感染的个体表明针对这些抗原的免疫应答有助于控制隐性感染者的认可。

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