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首页> 外文会议>International Colloquium on Paratuberculosis >The study of Mycobacterium avium subsp. paratuberculosis virulence in golden hamsters
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The study of Mycobacterium avium subsp. paratuberculosis virulence in golden hamsters

机译：分枝杆菌的研究。在金仓鼠的Paratuberculosis毒力

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Virulence of five isolates was investigated in golden hamsters (Mesocricetus auratus) line HAN:AURA. In the first experiment, 24 hamsters were infected with Mycobacterium avium subsp. paratuberculosis (MAP) cattle isolate of RFLP type B-C1 from a herd with a rapid spread of infection. Hamsters were infected per os (po), subcutaneously (sc), and intraperitoneally (ip), per eight animals in each group. Shedding of the causative agent through faeces was monitored for 7 months; after euthanasia the gastrointestinal tract was examined. Excreting of MAP of identical RFLP type was induced by all routes of infection and was observed during the whole period of the experiment. In the following experiment performed for 32 months, 96 hamsters were infected with four MAP isolates of three RFLP types: B-C1 from larvae of syrphid flies and from a patient with Crohn's disease (CD), A-C10 from cattle with a slow spread of infection, and D-C12 from a CD patient. Faeces were cultured on solid Herrold's egg yolk medium and liquid Long medium with Mycobactin J. The hamsters survived in average for 20.5 months (range 5-32 months). No signs of chronic
机译：在金仓鼠（Mesocricetus auratus）线汉族：光环中研究了五种分离物的毒力。在第一个实验中，24个仓鼠用分枝杆菌患者感染。 Paratuburisculosis（Map）牛分离RFLP型B-C1的牛群来自群体的感染迅速传播。仓鼠每组每八只动物皮下（PO），皮下（SC），腹腔内（SC）和腹膜内（IP）。通过粪便监测致病剂的脱落7个月;在安乐死后，检查了胃肠道。所有感染途径诱导相同RFLP型映射的排泄，并在实验的全天期间观察到。在以下实验中进行32个月，96种仓鼠感染了四种RFLP类型的四种地图分离株：来自Syrphid幼虫的B-C1，患有克罗恩病（CD）的患者，来自牛的A-C10，来自牛速度缓慢来自CD患者的感染和D-C12。粪便在固体Herrold的蛋黄培养基和液体长介质上用霉菌蛋白J.培养捕母平均幸存下来20.5个月（范围5-32个月）。没有慢性的迹象

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