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首页> 外文会议>International Association of Biomedical Gerontology International >Epidermal and Dermal Characteristics in Skin Equivalent after Systemic and Topical Application of Skin Care Ingredients
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Epidermal and Dermal Characteristics in Skin Equivalent after Systemic and Topical Application of Skin Care Ingredients

机译：皮肤和局部应用皮肤护理成分的皮肤表皮和皮肤特征

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Effects of active ingredients from topical and systemic skin-care products on structure and organization of epidermis, dermal-epidermal junction (DEJ), and dermis were examined using an in vitro reconstructed skin equivalent (SE). Imedeen Time Perfection (ITP) ingredients (a mixture of BioMarine Complex, grape seed extract, tomato extract, vitamin C) were supplemented systemically into culture medium. Kinetin, an active ingredient from Imedeen Expression Line Control Serum, was applied topically. Both treatments were tested separately or combined. In epidermis, all treatments stimulated keratinocyte proliferation, showing a significant increase of Ki67-positive keratinocytes (P < 0.05). Kinetin showed a twofold increase of Ki67-positive cells, ITP resulted in a fivefold, and ITP+kinetin showed a nine-fold increase. Differentiation of keratinocytes was influenced only by kinetin since filaggrin was found only in kinetin and kinetin+ITP samples. At the DEJ, laminin 5 was slightly increased by all treatments. In dermis, only ITP increased the amount of collagen type I. Both kinetin and ITP stimulated formation of fibrillin-1 and elastin deposition. The effect of kinetin was seen in upper dermis. It stimulated not only the amount of deposited fibrillin-1 and elastin fibers but also their organization perpendicularly to the DEJ. ITP stimulated formation of fibrillin-1 in deeper dermis. In summary, the combination of topical treatment with kinetin and systemic treatment with ITP had complementary beneficial effects in the formation and development of epidermis and dermis.
机译：使用体外重建的皮肤量（SE）检查局部和全身性护肤品的活性成分对表皮的结构和组织的影响和组织的影响，皮肤表皮连接（DEJ）和真皮。 IMEDEEN Time Perfection（ITP）成分（生物磁石复合物，葡萄籽提取物，番茄提取物，维生素C）全身均为培养基。 Kinetin，来自IMEDEEN表达线控制血清的活性成分局部探讨。两种治疗方法分别测试或组合。在表皮中，所有治疗刺激了角质形成细胞增殖，显示出Ki67阳性角质形成细胞的显着增加（P <0.05）。 Kinetin显示出Ki67阳性细胞的双重增加，ITP导致五倍，ITP + Kinetin显示九倍增加。由于仅在Kinetin和Kinetin + ITP样品中发现Filaggrin，因此仅通过Kinetin影响了角质形成细胞的分化。在DEJ，所有治疗都略微增加了Laminin 5。在真皮中，只有ITP增加胶原蛋白类型的量。Kinetin和ITP刺激成纤维蛋白-1和弹性蛋白沉积的形成。在高真皮中看到了Kinetin的效果。它不仅刺激了沉积的纤维蛋白-1和弹性蛋白纤维的量，而且垂直于DEJ的组织。 ITP在更深的真皮中刺激了纤维蛋白-1的形成。总之，用ITP与KINETIN和全身治疗的局部治疗组合在表皮和真皮的形成和发育中具有互补的有益作用。

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