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Vector-parasite Molecular Interactions: Malarial Molecules Essential for Parasite Invasion into the Host Mosquito Tissues

机译：载体寄生虫分子相互作用：寄生虫侵入到主体蚊子组织必需的疟原虫分子

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Parasites transmitted by vector insects recognize and infect specific tissues or cells of a specific vector species. Parasites express vector infective stage specific molecules that may interact with host cellular molecules. These specialized molecular mechanisms are believed to be essential for parasite infection and transmission by a vector. Mechanisms of host-parasite interactions are not well understood and species and tissue specificities cannot be explained well at the molecular level.We have analyzed malarial parasite proteins essential for invasion into host mosquito midgut cells in the rodent malaria, P. berghei. Some genes selected from ookinete ESTs were disrupted and their phenotypes analyzed. We found several molecules such as CTRP, CDPK, MAOP and CelTOS that function in parasite infection in the midgut epithelial cells.

机译：由载体昆虫传播的寄生虫识别和感染特异性载体物种的特异性组织或细胞。寄生虫表达可以与宿主细胞分子相互作用的载体感染阶段特异性分子。这些专用的分子机制被认为对寄生虫感染和载体传输至关重要。宿主寄生虫相互作用的机制尚不清楚，并且在分子水平下不能解释物种和组织特异性。我们分析了疟疾寄生虫蛋白质，该蛋白质蛋白质在啮齿动物疟疾中侵入麦克风中的蚊子中肠道细胞。从奥鲁蒂修斯ests选出的一些基因被破坏，并分析了它们的表型。我们发现了几种分子，如Ctrp，Cdpk，Maop和Celtos，该分子在中间肠细胞中的寄生虫感染中起作用。

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《International Congress of Parasitology》|2006年||共6页
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Y. Chinze;
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中图分类寄生虫病;
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1. Structure and Expression of an Adhesive Protein–like Molecule of Mosquito Invasive-stage Malarial Parasite [J] . Masao Yuda, Toshiki Sawai, Yasuo Chinzei The Journal of Experomental Medicine . 1999,第12期

机译：蚊侵袭阶段疟原虫的黏附蛋白样分子的结构和表达
2. Erythrocyte invasion by Babesia parasites: current advances in the elucidation of the molecular interactions between the protozoan ligands and host receptors in the invasion stage [J] . Yokoyama N, Okamura M, Igarashi I Veterinary Parasitology . 2006,第1a2期

机译：巴贝虫寄生虫对红细胞的入侵：在阐明入侵阶段原生动物配体与宿主受体之间的分子相互作用方面的最新进展
3. Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells [J] . Starnes GL, Coincon M, Sygusch J, Cell Host & Microbe . 2009,第4期

机译：醛缩酶对于宿主细胞寄生虫侵袭期间的能量产生和桥接粘附素-肌动蛋白细胞骨架相互作用至关重要
4. Vector-parasite Molecular Interactions: Malarial Molecules Essential for Parasite Invasion into the Host Mosquito Tissues [C] . Y. Chinze International Congress of Parasitology . 2006

机译：载体寄生虫分子相互作用：寄生虫侵入到主体蚊子组织必需的疟原虫分子
5. 1. Generation and characterization of mutants in the proteolytic processing site of the circumsporozoite protein (CSP) of Plasmodium berghei. 2. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: A new tool to study mosquito and mammalian host interactions with malaria parasites. [D] . Natarajan, Ramya. 2006

机译：1.伯氏疟原虫环子孢子蛋白（CSP）的蛋白水解加工位点中突变体的产生和表征。 2.伯氏疟原虫子孢子荧光体和促红细胞生成前阶段：研究蚊子和哺乳动物宿主与疟原虫相互作用的新工具。
6. Structure and Expression of an Adhesive Protein–like Molecule of Mosquito Invasive-stage Malarial Parasite [O] . Masao Yuda, Toshiki Sawai, Yasuo Chinzei 1999

机译：蚊侵袭阶段疟原虫的黏附蛋白样分子的结构和表达
7. Aldolase Is Essential for Energy Production and Bridging Adhesin-Actin Cytoskeletal Interactions during Parasite Invasion of Host Cells [O] . Starnes G. Lucas, Coincon Mathieu, Sygusch Jurgen, 2009

机译：醛缩酶对于能量产生和桥接宿主细胞的寄生虫侵袭过程中桥接粘附素-肌动蛋白细胞骨架相互作用至关重要。
8. International Symposium on Molecular, Genetic and Immunologic Studies of the Host-Parasite Interaction of the Intracellular Protozoan Parasite, Leishmania held in Cotswolds, England on December 3-6, 1985 [R] . McMahon-Pratt, D., Blackwell, J., Shaw, J. 1986

机译：1985年12月3日至6日在英国科茨沃尔德举行的利什曼原虫细胞内原生动物寄生虫宿主 - 寄生虫相互作用的分子，遗传和免疫学研究国际研讨会

Vector-parasite Molecular Interactions: Malarial Molecules Essential for Parasite Invasion into the Host Mosquito Tissues

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