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Immediate and Delayed Neuronal Effects of the Neonatal Administration of Dexamethasone

机译:地塞米松新生儿施用的立即和延迟神经元效应

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We have studied the short-term and long-term effects of a single dose of Dexamethasone upon the nervous system. Studies have been performed with 2 groups of 1.5 Wistar rats: I (control), II-2i/g Dexamethasone i.p,, during the first 24 hours of life, At 3 days old, we sacrificed 5 animals from each group; the others performed functional tests at 3 months old and then were sacrificed, At 3 days and 3 months old, we explored: the histological disorders, the neuronal viability, the cytochrome oxidase activity, the Mg-dependent AT-Pase activity from the cerebral cortex, hippocampus and hypothalamus, and oxidative stress parameters from the homogenates, Our results indicate the presence of immediate morphological, enzymatic and oxidative stress disorders in all the brain structures, partially reversible until the age of 3 months.
机译:我们已经研究了一剂地塞米松对神经系统的短期和长期影响。已经用2组1.5 Wistar大鼠进行研究:I(对照),II-2I / g Dexamethasone I.p,在生命的前24小时内,3天大,我们从每组中牺牲了5只动物;其他人在3个月内进行功能测试,然后在3天和3个月内处死,我们探讨了:组织学疾病,神经元活力,细胞色素氧化酶活性,来自脑皮层的Mg依赖性的At-Pase活性,海马和下丘脑,以及来自均质的氧化应激参数,我们的结果表明,在所有脑结构中,存在即时形态,酶促和氧化应激障碍,部分可逆直至3个月。

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