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Distribution of group A streptococcal virulence genes in group C and G streptococci

机译:C组中C组和G链球菌的链球菌毒力基因的分布

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Streptococcus dysgalactiae, subsp. equisimilis elicit a range of clinical manifestations similar to that of their close genetic relatives, group A streptococcus (GAS). The similarity in disease profiles raises questions as to the degree of genetic similarity between these two human pathogens, particularly in relation to virulence gene repertoires. In this study, we use a group A streptococcai virulence array comprising of 60 genes previously described as GAS virulence factors, and another 159 genes predicted to encode for extracellular proteins to examine the extent of their occurrence in 58 S. dysgalactiae subsp. equisimilis isolates. Between 25% and 50% of the genes represented on the array were present in the S. dysgalactiae subsp. equisimilis isolates. These observations highlight the similar virulence attributes of closely related human pathogenic streptococci.
机译:链球菌功能性,亚目前。 Equisimilis引发了一系列类似于其紧密基因亲属的临床表现物,组链球菌(气体)。疾病概况的相似性提出了这两个人病原体之间的遗传相似度的问题,特别是关于毒力基因曲目。在这项研究中,我们使用群体一种毒细胞毒力阵列,其包含预先描述为气体毒力因子的60个基因,并预测另外159个基因以编码细胞外蛋白,以检查其在58秒的患者中的发生程度。 Equisimilis隔离物。在S. Dysgalactiae Subsp中存在25%至50%的基因中所示的基因。 Equisimilis隔离物。这些观察结果突出了与密切相关的人致病链球菌的类似毒力属性。

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