• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Sub-speciating Campylobacter jejuni by Proteomic Analysis of Its Protein Biomarkers and Their Post-Translational Modifications
【24h】

Sub-speciating Campylobacter jejuni by Proteomic Analysis of Its Protein Biomarkers and Their Post-Translational Modifications

机译：通过蛋白质组分析蛋白质生物标志物和翻译后修改抑制振铃杆菌

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) can be used for the rapid identification of bacterial microorganisms by detection of their unique protein biomarkers. Pathogen identification involves mass spectral pattern recognition of an unknown microorganism to that of a mass spectra of a known microorganism. With the recent availability of microbial genomes, it is also possible to identify microbial protein biomarkers from comparison of observed and genomically predicted protein molecular weights (MW). However, this bioinformatics approach can be affected by the presence of biomarker post-translational modifications (PTMs) which change the MW of the biomarker. We have extracted and identified, by proteomic techniques, several protein biomarkers (and their PTMs) of three strains of Campylobacter jejuni an important foodborne pathogen.
机译：基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF-MS）可用于通过检测其独特的蛋白质生物标志物来快速鉴定细菌微生物。病原体鉴定涉及将未知微生物的质谱模式识别到已知微生物的质谱。随着近期微生物基因组的可用性，还可以从观察和基因组预测的蛋白质分子量（MW）的比较中鉴定微生物蛋白生物标志物。然而，这种生物信息学方法可以受到改变生物标志物MW的翻译后修饰（PTMS）的存在的影响。我们通过蛋白质组学技术提取和鉴定了三种弯曲杆菌的几种蛋白质生物标志物（及其PTMS），这是一个重要的食物载虫病原体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号