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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Identification of Nitrogen-Containing Compounds in Black Cohosh (Actaea racemosa L.) by Mass Spectrometric Dereplication
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Identification of Nitrogen-Containing Compounds in Black Cohosh (Actaea racemosa L.) by Mass Spectrometric Dereplication

机译：通过质谱识别Black Cohosh（Actaea Haremosa L.）中含氮化合物的鉴定

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Extracts of black cohosh (Actaea racemosa L., Cimicifuga racemosa) are under investigation as alternatives to hormone replacement therapy for the relief of menopausal symptoms such as hot flushes. Although the exact mechanisms of action remain uncertain, our preliminary studies indicate that black cohosh might act via modulation of serotonin 5-HT7 receptors (1). In our efforts to identify possible active constituents, we have implemented a mass spectrometric dereplication strategy that relies on accurate mass measurements combined with database searching to identify rapidly known compounds present in the extracts without the need for time-consuming isolation. Here we describe the identification of several previously unreported nitrogen containing compounds from a polar fraction of the methanolic extract of black cohosh.
机译：黑色Cohosh的提取物（Actaea Hatemosa L.，Cimicifuga Racemosa）是作为激素替代治疗的替代品，以缓解更年期症状，如热冲洗。虽然我们初步研究仍然不确定的确切行动机制表明，黑色COHOSH可能通过调节血清素5-HT7受体（1）。在我们努力识别可能的活性成分中，我们已经实施了一种质谱，其依赖于准确的质量测量与数据库搜索结合，以识别提取物中存在的快速已知的化合物，而不需要耗时的隔离。在这里，我们描述了来自黑色Cohosh的甲醇提取物的极性分数的几个先前未报告的含氮化合物的鉴定。

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