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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Top-down Proteomics by 12T-FTICR-MS for Characterizing Protein Biomarkers Discovered by SELDI
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Top-down Proteomics by 12T-FTICR-MS for Characterizing Protein Biomarkers Discovered by SELDI

机译：通过12T-FTICR-MS的自上而下的蛋白质组学，用于表征Seldi发现的蛋白质生物标志物

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Bronchoalveolar lavage fluid (BALF) contains an array of proteins that may serve as biomarkers of different disease states and conditions in the lungs of respiratory patients. Lung bacterial infections in Cystic Fibrosis (CF) patients are most devastating and new markers would be useful to identify infection type and stage, and response to therapy. SELDI can quickly screen clinical fluid samples for disease-associated proteins that can then be characterized with other technologies such as FTICR MS. SELDI is particularly useful for detecting proteins in the 2-20 kDa range, which is an appropriate range for FTICR monoisotopic mass measurements and top-down sequencing. Therefore, with its ultrahigh accuracy and resolution, 12T FTICR MS is the ideal instrument for characterizing SELDI-discovered biomarkers.
机译：Bronchoalveolar灌洗液（BALF）含有一系列蛋白质，可作为不同疾病状态的生物标志物和呼吸患者肺的病症。肺部细菌感染在囊性纤维化（CF）患者最毁灭性，新标志物可用于鉴定感染类型和阶段，并对治疗反应。 Seldi可以快速筛选用于疾病相关蛋白的临床流体样品，然后可以用其他技术如FTICR MS为特征。 Seldi对于检测2-20kDa范围中的蛋白质特别有用，这对于FTICR单同步体质量测量和自上而下测序是适当的范围。因此，由于其超高精度和分辨率，12T FTICR MS是用于表征Seldi发现的生物标志物的理想仪器。

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