Proteomic Profile of Keartinocytes and Skin in Response to the Induction of UV-irradiation and Chemical-Toxicant

机译：Kearcocytes和皮肤的蛋白质组学谱响应紫外线辐照和化学毒物的诱导

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Exposure to solar ultraviolet (UV) radiation, chemical carcinogens and chemical agents are primarily responsible for several skin diseases including skin cancer, skin tumor and dermatitis (1-4). In order to investigate the proteomics changes in response to solar irradiation and toxic chemical agents in the proteome of human keratinocytes (HaCaT cell line), two-dimensional difference gel electrophoresis (2-D DIGE) coupled to mass spectrometry were carried out for analyzing the global protein expression change. The in vivo proteomic profiles in response to environmental inductions are of clinical relevance to risk assessment applications and disease prevention.

机译：暴露于太阳紫外线（UV）辐射，化学致癌物和化学试剂主要负责几种皮肤疾病，包括皮肤癌，皮肤肿瘤和皮炎（1-4）。为了探讨蛋白质组学的变化，响应于人角质形成细胞蛋蛋白组（HaCAT细胞系）蛋蛋白质组的变化，进行与质谱偶联的二维差异凝胶电泳（2-D DIGE）进行分析全局蛋白质表达变化。响应于环境诱导的体内蛋白质组学谱系与风险评估应用和疾病预防有临床相关性。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2006年||共2页
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Shuqing Liu; Ming-Zhong Sun; Liming Liu; Thomas S McCormick; Kevin D. Cooper; Mark R. Chance;
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4. Proteomic Profile of Keartinocytes and Skin in Response to the Induction of UV-irradiation and Chemical-Toxicant [C] . Shuqing Liu, Ming-Zhong Sun, Liming Liu, ASMS Conference on Mass Spectrometry and Allied Topics . 2006

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Proteomic Profile of Keartinocytes and Skin in Response to the Induction of UV-irradiation and Chemical-Toxicant

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