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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Development of a Pulsed, Multiplexed, nano-Electrospray Ionization Source
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Development of a Pulsed, Multiplexed, nano-Electrospray Ionization Source

机译：开发脉冲，多路复用，纳米电喷雾电离源

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Nano-Electrospray Ionization Mass Spectrometry (nano-ESI-MS) has become an indispensable technique for the analysis of biologically relevant compounds.1 The ability to couple nano-ESI-MS to powerful separation methods (e.g. HPLC and CE) further increases the usefulness of this technique. While work has been published recently demonstrating the operation of several conventional ESI sources in a parallel, multiplexed arrangement to increase sample throughput, no work has yet been published regarding the multiplexing of two or more nano-ESI sources.2, 3 Consequently, the operational advantages of nano-ESI as compared to conventional ESI have not been fully realized for multiple sprayers; i.e. decreasing sample consumption and improving sensitivity. Furthermore, if the continuous nano-ESI process can be converted into a pulsed mechanism, the favorable characteristics of nano-ESI will be accomplished with the added advantage of even lower sample consumption.4 For this work a novel, dual nano-ESI source has been developed that can be controlled using applied voltages either in pulsed or continuous modes of operation.
机译：纳米电喷雾电离质谱（Nano-ESI-MS）已成为对生物相关化合物分析的不可或缺的技术.1将纳米ESI-MS对强大的分离方法（例如HPLC和CE）进行纳米ESI-MS的能力进一步增加了有用性这种技术。虽然工作已经发布了最近在并行，多路复用的安排中展示了几种传统ESI源的操作，以提高样本吞吐量，但在两个或更多个纳米ESI来源的复用，尚未发布任何工作，从而发布了两个或更多个纳米ESI来源。与传统ESI相比，纳米ESI的优点尚未完全实现多个喷雾器;即，降低样品消耗并提高灵敏度。此外，如果连续纳米ESI工艺可以转化为脉冲机​​构，则纳米ESI的有利特性将通过甚至更低的样品消耗的额外优点来实现.4对于这项工作，一种新的双纳米ESI源已经开发出，可以在脉冲或连续的操作模式下使用施加的电压来控制。

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