Mass Spectrometric Approaches for the Analysis of Biomarkers of Cocaine Addiction-related Behaviors

机译：可卡因成瘾行为的生物标志物分析的质谱方法

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Exposure to drugs of abuse, such as cocaine, is associated with long-term and progressively enhanced alterations in behavior. A complex interplay between dopamine, and other signaling molecules found in specific, reward-related brain regions, such as the striatum, is thought to mediate these changes. Progress in understanding addiction pathophysiology and its associated behavior can be facilitated by methods for fast, sensitive and simultaneous analysis of signaling molecules in relevant brain structures. In this work, we combine mass spectrometric technologies with rodent behavioral models of cocaine addiction for investigation of neuropeptides and small proteins in the brain regions implicated in addictive process.

机译：暴露于滥用药物，例如可卡因，与行为的长期和逐步增强的改变相关。多巴胺与特定的奖励相关脑区（例如纹章）的多巴胺和其他信号分子之间的复杂相互作用被认为介导这些变化。通过相关脑结构中的信号分子快速，敏感和同时分析信号分子的方法，可以促进理解成瘾病理生理学及其相关行为的进展。在这项工作中，我们将质谱与可卡因成瘾啮齿动物行为模型相结合，以对升值过程中致癌的脑区中神经肽和小蛋白质的研究。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2006年||共2页
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Elena V. Romanova; Jessica Stanis; Joshua M. Gulley; Stanislav S. Rubakhin; Jonathan V. Sweedler;
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中图分类 TB994.5-53;
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入库时间 2022-08-20 19:43:42

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Mass Spectrometric Approaches for the Analysis of Biomarkers of Cocaine Addiction-related Behaviors

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