Insulin induced-changes of the tyrosine phosphoproteom of brown preadipocytes and adipocytes

机译：胰岛素诱导棕色前脂肪细胞和脂肪细胞酪氨酸磷蛋白蛋白酶的变化

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Type 2 diabetes is characterized by insulin resistance in muscle, liver, and fat and by defects in insulin secretion from pancreatic (beta)-cells. Insulin binding to its receptor initiates a complex network of events beginning with the activation of a tyrosine phosphorylation cascade that branches out to affect multiple endpoints. In order to precisely define the tyrosine-phosphoproteome of the insulin signaling pathway we employed stable isotope labeling by amino acids in cell culture (SILAC) in insulin stimulated and unstimulated brown wilde-type adipocytes. To determine more pecisely the roles of the insulin receptor substrate 1 and IRS-2 we compared IGF-1 induced changes of tyrosine phosphorylation in wilde-type, IRS-1, and IRS-2 deficient brown preadipocytes.

机译：2型糖尿病的特征在于肌肉，肝脏和脂肪中的胰岛素抗性以及胰岛素分泌的缺陷来自胰腺（β） - 细胞。与其受体的胰岛素结合引发了一种从分支出来影响多个终点的酪氨酸磷酸化级联的激活开始的复杂事件网络。为了精确地定义胰岛素信号传导途径的酪氨酸 - 磷蛋白酶，我们采用胰岛素（Silac）中的氨基酸稳定同位素标记，胰岛素刺激和未刺激的褐色野生型脂肪细胞。为了更新胰岛素受体基质1和IRS-2的作用，我们将IGF-1诱导的酪氨酸磷酸化变化与野生型，IRS-1和IRS-2缺乏棕色前脂肪细胞中的抗蛋白酶磷酸化进行比较。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2006年||共2页
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M. Krueger; I. Kratchmarova; B. Blagoev; YH. Tseng; CR. Kahn; Matthias Mann;
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机译：异寡糖原蛋白通过抑制3T3-L1前脂肪细胞中的蛋白质酪氨酸磷酸酶1B氧化来损害胰岛素信号传导和脂肪细胞分化
2. Liver X receptor agonists ameliorate TNFα-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression [J] . S. Fernández-Veledo, I. Nieto-Vazquez, C. M. Rondinone, Diabetologia . 2006,第12期

机译：肝X受体激动剂通过下调蛋白酪氨酸磷酸酶1B基因表达来改善TNFα诱导的鼠棕色脂肪细胞胰岛素抵抗。
3. Secretion of Adipocytes and Macrophages under Conditions of Inflammation and/or Insulin Resistance and Effect of Adipocytes on Preadipocytes under These Conditions [J] . Yu-Tao Wei, Dong-Sheng Xia, Wen-Kai Yang Biochemistry . 2014,第7期

机译：炎症和/或胰岛素抵抗条件下脂肪细胞和巨噬细胞的分泌以及在这些条件下脂肪细胞对脂肪细胞的影响
4. Insulin induced-changes of the tyrosine phosphoproteom of brown preadipocytes and adipocytes [C] . M. Krueger, I. Kratchmarova, B. Blagoev, ASMS Conference on Mass Spectrometry and Allied Topics . 2006

机译：胰岛素诱导棕色前脂肪细胞和脂肪细胞酪氨酸磷蛋白蛋白酶的变化
5. The role of adiponectin on body composition, adipocyte differentiation, preadipocyte proliferation and its modulation of inflammation with high fat diets [D] . Braucher, Douglas Robert. 2010

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机译：Sargassum serratifolium中的Sargahydroquinoic酸通过诱导白色脂肪细胞褐变来激活3T3-L1前脂肪细胞中的脂质分解代谢途径（P06-108-19）
7. Rosiglitazone produces insulin sensitisation by increasing expression of the insulin receptor and its tyrosine kinase activity in brown adipocytes [O] . R. Hernandez, T. Teruel, M. Lorenzo 2003

机译：Rosiglitazone通过增加胰岛素受体的表达及其在棕色脂肪细胞中的表达及其酪氨酸激酶活性产生胰岛素敏化

Insulin induced-changes of the tyrosine phosphoproteom of brown preadipocytes and adipocytes

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