Dissociation Studies of Alkali Metal Cation Complexes of Aspartic Acid, Glutamic Acid, Asparagine, and Glutamine

机译：天冬氨酸，谷氨酸，天冬酰胺和谷氨酰胺碱金属阳离子络合物的解离研究

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

The enzymatic transfer of Na~(+) and K~(+) across cellular membranes is necessary for maintenance of cellular function. Quantitative information about metal cation binding to amino acids should help our understanding of interactions associated with this process, particularly in the Na~(+)-K~(+)-ATPase enzyme. Another significant biological process is the deamidation of proteins, which occurs most prominently at asparaginyl residues. In fact, the deamidation of asparagine is the most commonly observed form of post-translational protein modification. This spontaneous process plays both productive and destructive roles in protein processing and has been linked to a number of degenerative diseases. We have found that the Na~(+)(Asn) complex undergoes deamidation to form Na~(+)-bound 3-amino succinic anhydride, Na~(+)(a-SA), the direct analogue of the physiologically relevant intermediates formed by deamidation. Therefore, analysis of the deamidation process observed in the Na~(+)(Asn) system has valuable biological implications.

机译：在细胞膜穿过细胞膜的酶转移是维持细胞功能所必需的。关于金属阳离子结合到氨基酸的定量信息应该帮助我们的与此方法中特别以Na〜（+）相关联的，相互作用的了解 - K〜（+） - ATP酶的酶。另一种显着的生物学过程是蛋白质的脱染，其在浅氨氨基氨基残基中最突出地发生。事实上，天冬酰胺的脱酰胺是最常见的翻译后蛋白质改性形式。这种自发过程在蛋白质加工中起着生产性和破坏性的作用，并与许多退行性疾病联系起来。我们发现Na〜（+）（ASN）复合物经历脱酰胺以形成Na〜（+） - 结合的3-氨基琥珀酸酐，Na〜（+）（A-SA），生理相关的中间体的直接类似物通过脱染形成。因此，在NA〜（+）（ASN）系统中观察到的脱酰胺方法的分析具有有价值的生物学意义。

著录项

来源
《ASMS Conference on Mass Spectrometry and Allied Topics》|2008年||共2页
会议地点
作者
Amy L. Heaton; Robert M. Moision; Peter B. Armentrout;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. Experimental and theoretical studies of sodium cation complexes of the deamidation and dehydration products of asparagine, glutamine, aspartic acid, and glutamic acid [J] . Heaton AL, Ye SJ, Armentrout PB The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory . 2008,第15期

机译：天门冬酰胺，谷氨酰胺，天冬氨酸和谷氨酸脱氨基和脱水产物的钠阳离子配合物的实验和理论研究
2. Synthesis and characterization of four new manganese(III) complexes and amino acid (L-aspartic acid, L-asparagine, L-glutamic acid, L-glutamine) Schiif bases [J] . Iffet Sakiyan Transition Metal Chemistry . 2007,第1期

机译：四种新型锰（III）配合物和氨基酸（L-天冬氨酸，L-天冬酰胺，L-谷氨酸，L-谷氨酰胺）Schiif碱的合成与表征
3. Synthesis and characterization of four new manganese(III) complexes and amino acid (L-aspartic acid, L-asparagine, L-glutamic acid, L-glutamine) Schiff bases [J] . ?ffet ?ak?yan Transition Metal Chemistry . 2007,第1期

机译：四种新型锰（III）配合物和氨基酸（L-天冬氨酸，L-天冬酰胺，L-谷氨酸，L-谷氨酰胺）席夫碱的合成与表征
4. Dissociation Studies of Alkali Metal Cation Complexes of Aspartic Acid, Glutamic Acid, Asparagine, and Glutamine [C] . Amy L. Heaton, Robert M. Moision, Peter B. Armentrout ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：天冬氨酸，谷氨酸，天冬酰胺和谷氨酰胺碱金属阳离子络合物的解离研究
5. Mass spectrometric studies on alkali metal cationized amino acids and peptides. [D] . Tsang, Yuet. 2004

机译：碱金属阳离子化氨基酸和多肽的质谱研究。
6. Thermal decomposition of the amino acids glycine cysteine aspartic acid asparagine glutamic acid glutamine arginine and histidine [O] . Ingrid M. Weiss, Christina Muth, Robert Drumm, 2018

机译：氨基酸甘氨酸半胱氨酸天冬氨酸天冬酰胺谷氨酸谷氨酰胺精氨酸和组氨酸的热分解
7. Thermal decomposition of the amino acids glycine, cysteine, aspartic acid, asparagine, glutamic acid, glutamine, arginine and histidine [O] . Ingrid M. Weiss, Christina Muth, Robert Drumm, 2018

机译：氨基酸甘氨酸的热分解，半胱氨酸，天冬氨酸，天冬酰胺，谷氨酸，谷氨酰胺，精氨酸和组氨酸
8. Plasma and Urinary Levels of L-Asparaginase, L-Asparagine, L-Glutamine, Aspartic Acid and Plasma Ammonia Levels in a Beagle Dog Treated with 1,000 I.U./Kg/Day X 5 of L-Asparaginase [R] . Rakieten, N., Cooney, D. A., Davis, R. D. 1970

机译：用1,000 I.U./Kg/Day X 5 L-天冬酰胺酶处理的Beagle犬血浆和尿液中L-天冬酰胺酶，L-天冬酰胺，L-谷氨酰胺，天冬氨酸和血浆氨水平

Dissociation Studies of Alkali Metal Cation Complexes of Aspartic Acid, Glutamic Acid, Asparagine, and Glutamine

摘要

著录项

相似文献

相关主题

期刊订阅