THE MTOR SIGNALING PATHWAY AND ITS INFLUENCE ON THE MHC CLASS I PEPTIDE REPERTOIRE

机译：MTOR信号通路及其对MHC类I肽曲目的影响

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

1) The MIP repertoire can be monitored dynamically using high-throughput MS-based quantitative approach. 2) A progressive increase in the proportion of differentially abundant MHC I peptides was observed up to 48 h following mTOR inhibition. 3) Prolonged mTOR inhibition led to a significant increase in abundance of 18percent of the MIP repertoire. 4) Expression levels of peptide-source proteins over expressed after mTOR inhibition suggest that different post-translational mechanisms account for the generation of those peptides.

机译：1）可以使用基于高吞吐量MS的定量方法动态监测MIP曲目。 2）在MTOR抑制后观察到差异丰富的MHC I肽比例的比例增加。 3）延长的MTOR抑制导致MIP曲目的18°的大量增加。 4）MTOR抑制后表达的肽源蛋白的表达水平表明，不同的翻译后机制占那种肽的产生。

著录项

来源
《ASMS Conference on Mass Spectrometry and Allied Topics》|2008年||共1页
会议地点
作者
Marie-Helene Fortier; Etienne Caron; Mathieu Courcelles; Claude Perreault; Pierre Thibault;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation. [J] . Fortenbery NR, Paraiso KH, Taniguchi M, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2010,第9期

机译：SHIP影响CD48和MHC I类配体的信号，这些配体调节NK细胞的稳态，效应子功能和库形成。
2. SHIP Influences Signals from CD48 and MHC Class I Ligands That Regulate NK Cell Homeostasis, Effector Function, and Repertoire Formation [J] . Nicole R. Fortenbery, Kim H. T. Paraiso, Masaru Taniguchi, The journal of immunology . 2010,第9期

机译：SHIP影响CD48和MHC I类配体调节NK细胞稳态，效应子功能和库形成的信号
3. MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL. [J] . Deng Y, Yewdell JW, Eisenlohr LC, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1997,第4期

机译：MHC亲和力，肽释放，T细胞库和免疫优势都有助于缺乏抗病毒CTL识别的MHC I类限制性肽。
4. THE MTOR SIGNALING PATHWAY AND ITS INFLUENCE ON THE MHC CLASS I PEPTIDE REPERTOIRE [C] . Marie-Helene Fortier, Etienne Caron, Mathieu Courcelles, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：MTOR信号通路及其对MHC类I肽曲目的影响
5. Anti-MHC class I antibody-mediated activation of cell proliferation and survival signaling pathways in endothelial cells. [D] . Jindra, Peter Thomas. 2007

机译：抗MHC I类抗体介导的内皮细胞增殖和存活信号通路的激活。
6. Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition [O] . 1993

机译：埋在主要组织相容性复合物（MHC）I类结合裂隙中的肽残基的变化会影响T细胞识别：I类MHC或结合肽的间接构象改变在确定T细胞识别中的可能作用
7. SHIP Influences Signals from CD48 and MHC Class I Ligands That Regulate NK Cell Homeostasis, Effector Function, and Repertoire Formation [O] . Nicole R. Fortenbery, Kim H. T. Paraiso, Masaru Taniguchi, 2010

机译：船舶影响来自CD48和MHC级别的信号调节NK CelloosoTasis，效应功能和曲目形成的信号

THE MTOR SIGNALING PATHWAY AND ITS INFLUENCE ON THE MHC CLASS I PEPTIDE REPERTOIRE

摘要

著录项

相似文献

相关主题

期刊订阅