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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >High-performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Investigating the Effect of Drinking Red Wine on Urine Metabolome
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High-performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Investigating the Effect of Drinking Red Wine on Urine Metabolome

机译：高性能化学同位素标记液相色谱质谱法，用于研究饮用红葡萄酒对尿代谢的影响

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Urine is a human biofluid that is widely used for searching potential metabolite biomarkers of diseases. Ideally, the metabolome profiles generated from comparative groups of individuals should contain endogenous metabolites that indicate the health states of the individuals. However, the intake of food prior to the collection of urine may induce changes in the urine metabolome profile by introducing a significant amount of exogenous metabolites. Red wine is a widely consumed drink and its overall impact on the human metabolome composition is not widely known. In this work, a highly sensitive dansylation isotope labeling liquid chromatography mass spectrometry method was developed for determining red wine profiles. Human urine samples before and after drinking red wine were analyzed to determine exogenous metabolites.
机译：尿液是一种人生物流体，广泛用于寻找潜在的代谢产物生物标志物。理想情况下，从个体的比较组产生的代谢物谱应含有内源性代谢物，表明个人的健康状况。然而，通过引入大量外源代谢物，在尿液收集之前的食物可能会诱导尿代谢谱的变化。红葡萄酒是一种广泛消耗的饮料，其对人类代谢组合物的整体影响并不广泛。在这项工作中，开发了一种高敏化的丹阳化同位素标记液相色谱法质谱法，用于确定红葡萄酒型材。分析饮用红葡萄酒前后的人类尿液样品以确定外源代谢物。

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