In Vitro Hepatic Metabolism of Licochalcone A, a Chalcone from the Licorice Species Glycyrrhiza inflata

机译：Licochalcone A的体外肝脏代谢，来自甘草属甘酮的胆酮甘霉素膨胀

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Licochalcone A formed five (5) Phase I mono- or di-oxygenated metabolites (MW: M1, M2, M3 = 354; M4, M5 = 370) during incubation with human liver microsomes. MS/MS analysis indicated addition of one oxygen atom to the A-ring, B-ring or both. The CYP450 isozymes involved in the formation of major phase I metabolites were determined. These in vitro data will help predict human bioavailability and metabolism of LicA from licorice.

机译：Licochalcone在与人肝微粒体孵育期间形成的五（5）个相I单 - 或二氧化代谢物（MW：M1，M2，M3 = 354; M4，M5 = 370）。 MS / MS分析表明向A形环，B环或两者中加入一个氧原子。确定参与主要相1代谢物的CYP450同工酶。这些体外数据将有助于预测来自甘草的人类生物利用度和LiCa的代谢。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2016年|1CD|共1页
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Lingyi Huang; Dejan Nikolic; Richard B. van Breemen;
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1. Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice ( Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry [J] . Lingyi Huang, Dejan Nikolic, Richard B. van Breemen Analytical and bioanalytical chemistry . 2017,第30期

机译：Licochalcone A的肝脏代谢，来自甘草的潜在化学预防性Chalcone（<强调型=“斜体”>甘草型“> Glycyrrhiza灌输），使用液相色谱 - 串联质谱法测定
2. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. [J] . Furusawa J, Funakoshi-Tago M, Mashino T, International immunopharmacology . 2009,第4期

机译：源自甘草膨胀的查耳酮，Licochalcone A，Licochalcone B和Licochalcone D抑制LPS信号通路中NF-κBp65的磷酸化。
3. Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease [J] . Natural product research . 2020,第4a6期

机译：Licochalcone B，来自Glycyrrhiza Inflata的Chalcone衍生物，作为治疗阿尔茨海默病的多功能试剂
4. In Vitro Hepatic Metabolism of Licochalcone A, a Chalcone from the Licorice Species Glycyrrhiza inflata [C] . Lingyi Huang, Dejan Nikolic, Richard B. van Breemen ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：Licochalcone A的体外肝脏代谢，来自甘草属甘酮的胆酮甘霉素膨胀
5. Isolation and identification of cytotoxic compounds from licorice (Glycyrrhiza glabra) and Vietnamese coriander (Polygonatum odoratum). [D] . Vastano, Bret Charles. 2001

机译：从甘草（Glycyrrhiza glabra）和越南香菜（Polygonatum odoratum）中分离和鉴定细胞毒性化合物。
6. Hepatic metabolism of licochalcone A a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata) determined using liquid chromatography-tandem mass spectrometry [O] . Lingyi Huang, Dejan Nikolic, Richard B. van Breemen -1

机译：使用液相色谱-串联质谱法测定的甘草（甘草）潜在的化学预防查尔酮licochalcone A的肝代谢
7. Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. Inflata Extracts Modulate Estrogen Metabolism in ACI Rats [O] . Shuai Wang, Tareisha L. Dunlap, Lingyi Huang, 2018

机译：甘草化学预防和恢复力活性的证据：甘草唑和G. intaTata提取物调节ACI大鼠的雌激素代谢
8. Comparison of In vitro Methods and the In vivo Metabolism of Lindane for Assessing the Effects of Repeated Administration of Ethanol on Hepatic Drug Metabolism [R] . Trela, B. A. , Carlson, G. P. , Chadwick, R. W. , 1985

机译：体外方法与林丹体内代谢评估重复给予乙醇对肝脏药物代谢影响的比较

In Vitro Hepatic Metabolism of Licochalcone A, a Chalcone from the Licorice Species Glycyrrhiza inflata

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