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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Analysis of Retinal Degeneration in a Leber Congenital Amaurosis Mouse Model Using High Spatial Resolution MALDI-Imaging Mass Spectrometry
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Analysis of Retinal Degeneration in a Leber Congenital Amaurosis Mouse Model Using High Spatial Resolution MALDI-Imaging Mass Spectrometry

机译：利用高空间分辨率MATDI成像质谱法分析LEBER先天性生物疲劳小鼠模型的视网膜变性

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Utilizing DIC microscopy in conjunction with fiducial markers significantly improved the accuracy to determine the tissue origin of the species observed in the MALDI IMS in relation to the optical image of the tissue. This approach will assist in identification of these species since the correct region (photoreceptors, inner neuronal retina or RPE) of tissue can now be isolated to improve sensitivity. The localization of these signals will also bring greater understanding of the role RPE65 gene in the visual cycle as molecular constituents originating from the inner neuronal retina not the RPE, have been effected. These data suggest the RPE65 gene affects the visual cycle in a number of varying pathways which expand beyond the retinal pigment epithelium.
机译：利用DIC显微镜与基准标记的结合显着提高了确定MALDI IMS中观察到的物种的组织来源的准确性，相对于组织的光学图像。这种方法将有助于鉴定这些物种，因为现在可以分离组织的正确区域（感光体，内神经元视网膜或RPE）以提高灵敏度。这些信号的定位还将提高视觉循环中的作用RPE65基因作为源自内部神经元视网膜的分子成分，已经进行了源自没有RPE的分子成分。这些数据表明RPE65基因在许多不同的途径中影响视觉循环，该途径扩展到视网膜颜料上皮。

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