首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >QUANTIFICATION OF THE ANTIBODY DRUG CONJUGATE, TRASTUZUMAB EMTANSINE, AND THE MONOCLONAL ANTIBODY, TRASTUZUMAB, IN PLASMA USING A GENERIC KIT-BASED APPROACH

【24h】

QUANTIFICATION OF THE ANTIBODY DRUG CONJUGATE, TRASTUZUMAB EMTANSINE, AND THE MONOCLONAL ANTIBODY, TRASTUZUMAB, IN PLASMA USING A GENERIC KIT-BASED APPROACH

机译：使用通用套件的方法定量抗体药物缀合物，曲妥珠单抗蛋白和单克隆抗体，曲妥珠单抗，血浆中的血浆

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Using a generic kit-based approach, total antibody quantification of a mAb therapeutic (Trastuzuamb) and ADC (Trastuzumab Emtansine) was achieved with successful detection and identification of miscleavage peptides. Quantification limits of 0.5-1 μg/mL were achieved, while maintaining excellent linearity, precision and accuracy. The universal, kit-based approach allows scientists to achieve high sensitivity with a simple step-wise protocol and standardized, pre-measured reagents, ensuring both the sensitivity and reproducibility required in discovery studies to make time sensitive and critical project decisions.

机译：使用基于通用的试剂盒的方法，通过成功检测和鉴定切片肽，实现了MAB治疗（曲抗uamm）和ADC（曲妥珠珠胺Omtansine）的总抗体定量。实现了0.5-1μg/ ml的定量限制，同时保持优异的线性度，精度和精度。基于套件的套件的方法使科学家能够通过简单的迈出方案和标准化，预测量的试剂来实现高灵敏度，确保发现研究中所需的灵敏度和再现性，以制定时间敏感和关键的项目决策。

著录项

来源
《ASMS Conference on Mass Spectrometry and Allied Topics》|2016年|1CD|共1页
会议地点
作者
Hua Yang; Mary Lame; Sherri Naughton; Erin Chambers;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. Stability assessment of antibody-drug conjugate Trastuzumab emtansine in comparison to parent monoclonal antibody using orthogonal testing protocol [J] . Hoda E. Mohamed, Abeer A. Mohamed, Medhat A. Al-Ghobashy, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2018,第期

机译：使用正交试验方案的母体单克隆抗体相比，抗体药物缀合物曲妥珠单抗的稳定性评估
2. Antibody-drug conjugates in oncology: From the concept to trastuzumab emtansine (T-DM1) [Lesanticorps conjugu??s en oncologie: Du concept au trastuzumab emtansine (T-DM1)] [J] . Gon莽alvesA., Tr茅danO., VillanuevaC., Bulletin du Cancer: Journal de l'Association Francaise pour l'Etude du Cancer . 2012,第12期

机译：肿瘤药物抗体偶联物：从概念到曲妥珠单抗（T-DM1）[Lesanticorps conjugu？s encologie：杜概念曲妥珠单抗（T-DM1）]
3. LC-HRMS quantitation of intact antibody drug conjugate trastuzumab emtansine from rat plasma [J] . Jin Wen, Burton Lyle, Moore Ian Bioanalysis . 2018,第11期

机译：LC-HRMS定量完整抗体药物缀合物从大鼠等离子体中的曲妥珠单抗
4. QUANTIFICATION OF THE ANTIBODY DRUG CONJUGATE, TRASTUZUMAB EMTANSINE, AND THE MONOCLONAL ANTIBODY, TRASTUZUMAB, IN PLASMA USING A GENERIC KIT-BASED APPROACH [C] . Hua Yang, Mary Lame, Sherri Naughton, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用通用套件的方法定量抗体药物缀合物，曲妥珠单抗蛋白和单克隆抗体，曲妥珠单抗，血浆中的血浆
5. Comparison of the Measured Biodistribution of 212Pb-Radiolabeled Monoclonal Antibodies (Trastuzumab) in Mice with 232Th and Progeny in Human Reticuloendothelial Tissue Measured Using Alpha Particle Track Autoradiographic Microdosimetry from Thorotrast [D] . Schneider, Nathaniel R. 2019

机译：用α粒子轨道放射性微型微量血管测量的232th和后代在钍术中测量的232次和后代的小鼠212pB-放射性标记的单克隆抗体（Trastuzumab）对小鼠的测量生物分布的比较
6. Native mass spectrometry and ion mobility characterization of trastuzumab emtansine a lysine-linked antibody drug conjugate [O] . Julien Marcoux, Thierry Champion, Olivier Colas, 2015

机译：曲妥珠单抗Emtansine（一种赖氨酸连接的抗体药物偶联物）的天然质谱和离子迁移率表征
7. A Novel Anti-HER2 Antibody–Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine [O] . Vadim Le Joncour, Ana Martins, Maija Puhka, 2019

机译：一种新的抗HER2抗体 - 药物缀合物XMT-1522，用于HER2阳性乳腺和耐胃癌的胃癌

QUANTIFICATION OF THE ANTIBODY DRUG CONJUGATE, TRASTUZUMAB EMTANSINE, AND THE MONOCLONAL ANTIBODY, TRASTUZUMAB, IN PLASMA USING A GENERIC KIT-BASED APPROACH

摘要

著录项

相似文献

相关主题

期刊订阅