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首页> 外文会议>IUPAC International Congress of Pesticide Chemistry >Synthesis and Inhibitory Action of Novel Acetogenin Mimics Alac-Acetogenins: A New Class of Inhibitors of Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex-I)
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Synthesis and Inhibitory Action of Novel Acetogenin Mimics Alac-Acetogenins: A New Class of Inhibitors of Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex-I)

机译：新型丙酮糖素模拟物的合成及抑制作用Alac-acetogens：一种新的线粒体Nadh-ubiquinone氧化还原酶抑制剂（复合物-I）

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18.1 Introduction NADH-ubiquinone oxidoreductase (Complex I) is the first energy-transducing enzyme of the respiratory chains of most mitochondria and many bacteria. It catalyzes the oxidation of NADH by ubiquinone, coupled to the generation of an electrochemical proton gradient across the membrane that drives energy-consuming processes such as ATP synthesis and flagella movement [1]. Complex I is the most complicated multisubunits enzyme in the respiratory chain; e.g., the enzyme from bovine heart mitochondria is composed of 46 different subunits with a total molecular mass of about 1 MDa [2]. Recently, the crystal structure of the hydrophilic domain (peripheral arm) of Complex I from Thermus thermophilus was solved at 3.3 angstrom resolution [3]. However, our knowledge about the functional and structural features of the membrane arm, such as the ubiquinone redox reaction, proton translocation mechanism, and mode of action of numerous specific inhibitors, is still very limited [4—5].
机译：18.1简介NADH-泛烯酮氧化还原酶（复合物I）是大多数线粒体和许多细菌的呼吸链的第一酶。它催化NADH的由泛醌氧化，穿过膜耦合到电化学质子梯度的产生驱动耗能过程，如ATP合成和鞭毛运动[1]。复杂的I是呼吸链中最复杂的多信号酶;例如，来自牛心脏线粒体的酶由46个不同的亚基组成，其总分子量为约1 mda [2]。最近，从嗜热菌复合物I的亲水结构域（外周臂）的晶体结构在3.3埃分辨率[3]求解。然而，我们关于膜臂的功能和结构特征的知识，例如泛醌氧化还原反应，质子易位机制和许多特异性抑制剂的作用方式，仍然非常有限[4-5]。

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