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Calorie Restriction, Post-reproductive Life Span, and Programmed Aging A Plea for Rigor

机译:卡路里限制,繁殖后的寿命,以及严谨的辩护

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All scientists are acutely aware of the profound challengethat they face when communicating scientific findings to nonscientists,especially when great uncertainty is involved and when the topic is ofpersonal interest to the general public. Simplification of the issues—sometimes extending to a degree of oversimplification—is a sad but gen-erally recognized necessity. It is not, however, a necessity when scientistscommunicate with each other, and when that happens, the explanationmay lie elsewhere: either in the speaker's vested interests or in over-confidence on the speaker's part in the extent to which he or she hasgrasped the topic under discussion. Both these explanations are seriousallegations and must not be made without good reason, not least becausean alternative explanation is often the entirely legitimate preference forscientific "shorthand." However, when a general tendency toward over-simplification emerges within an expert community, not only in informalinteractions but in learned publications, the field in question can suffera loss of reputation for rigor, which may especially infect younger sci-entists joining that field (or contemplating joining it). I feel that thishas occurred to a dangerous degree within biogerontology in respect ofthe way in which the effect of the environment on the rate of aging—whether that of an individual organism or of a lineage—is described.There are still important controversies in that area, but I refer herestrictly to issues concerning which a thorough consensus exists. In thisessay I highlight some fundamental tenets of biogerontology that arefrequently, and to my mind problematically, mis-stated by many in thisfield in their printed pronouncements. Greater precision on these pointswill, I believe, benefit biogerontology at many levels, avoiding confusionamong biogerontologists, among other biologists, and among the generalpublic.
机译:当所有科学家们都敏锐地意识到他们对非科学发现的科学发现,特别是当涉及巨大的不确定性以及普通公众的敌人兴趣时,他们面临着深刻的挑战。简化问题 - 有时延伸到过度简化程度 - 是一种令人伤心的但是基因易懂的必要性。然而,当科学家社会彼此相互作用时,并且当发生这种情况时,它不是必需品,解释者在其他地方谎言:要么在扬声器的既得利益或对演讲者的过度信心中,在他或她的争夺者的范围内正在讨论中。这两种解释都是严肃的,不得没有得到充分理由的制造,并非最不重要的替代解释往往是完全合法的偏好,而是完全合法的偏爱“速记”。然而,当专家社区中出现的一般倾向于专家社区时,不仅在非线性互动中,而且在学习出版物中,所讨论的领域就可以削弱严谨的声誉,这可能尤其是感染更年轻的SCI-Indist加入该领域(或考虑加入它)。我觉得在生物阴化学的危险程度上致力于环境对老化率的影响 - 是否描述了个体生物或血统 - 被描述。该领域仍然存在重要争议但是,我提交批发致力于存在全面共识的问题。在ThiceSayay中,我突出了一些生物阴极学的基本原则,并且在他们的印刷声明中,许多人错误地说明了我的思想。我认为,在这些尖端的精度更高,我认为,在许多层面受益生物化学,避免困惑的杂志生物学家,以及其他生物学家和普通公共。

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