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MASS SPECTROMETRY EVALUATION OF CIRCULATING S100A8 AND S100A9 PROTEINS AS PROGNOSIS BIOMARKERS IN SEPSIS

机译：循环S100A8和S100A9蛋白作为脓毒症预后生物标志物的质谱评价

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Sepsis causes one death every 5.2 seconds worldwide [1]. To achieve rapid patient care, prognostic markers are needed. Predictive value of S100A8/9 complex was recently highlighted with an ELISA[2]. However, antibody affinity to particular isoform is questionable. Our study has assessed the prognostic value of plasmatic S100A8 and S100A9 by combining intact protein mass spectrometry for isoform characterization and bottom-up quantification of total isoforms.

机译：败血症每5.2秒导致一次死亡[1]。为了实现快速的患者护理，需要预后标志物。最近用ELISA突出显示S100A8 / 9复合物的预测值[2]。然而，对特定同种型的抗体亲和力是可疑的。我们的研究通过将完整的蛋白质质谱法组合用于同种型的表征和自下而上的定量来评估等离子体S100a8和S100a9的预后值。

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《International Mass Spectrometry Conference》|2018年|p1-627|共2页
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Christelle Dubois; Didier Payen; Valerie Faivre; Stephanie Simon; Francois Fenaille; Christophe Junot; Nathalie Morel; Fran?ois Becher;
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中图分类分析化学;
关键词
sepsis; plasma; S100A8/S100A9; biomarker; PRM;

机译：败血症;等离子体;S100A8 / S100A9;生物标志物;PRM;

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机译：一种多重液相色谱多重反应监测质谱（LC-MRM / MS）方法，用于评估唾液蛋白作为口服癌生物标志物
2. Evaluation of mass spectrometry of urinary proteins and peptides as biomarkers for cats at risk of developing azotemia [J] . Jepson Rosanne E., Coulton Gary R., Cowan Matthew L., American Journal of Veterinary Research . 2013,第2期

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3. Evaluation of multiprotein immunoaffinity subtraction for plasma proteomics and candidate biomarker discovery using mass spectrometry [J] . Liu T, Qian WJ, Mottaz HM, Molecular & cellular proteomics: MCP . 2006,第11期

机译：使用质谱法评估血浆蛋白质组学和候选生物标志物的多蛋白免疫亲和减法
4. MASS SPECTROMETRY EVALUATION OF CIRCULATING S100A8 AND S100A9 PROTEINS AS PROGNOSIS BIOMARKERS IN SEPSIS [C] . Christelle Dubois, Didier Payen, Valerie Faivre, International Mass Spectrometry Conference . 2018

机译：循环S100A8和S100A9蛋白作为脓毒症预后生物标志物的质谱评价
5. Circulating mitochondrial and bacterial DNA as biomarkers of sepsis [D] . Kisat, Mehreen T. 2016

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6. Development of a Multiplexed Liquid Chromatography Multiple-Reaction-Monitoring Mass Spectrometry (LC-MRM/MS) Method for Evaluation of Salivary Proteins as Oral Cancer Biomarkers [O] . Yi-Ting Chen, Hsiao-Wei Chen, Chun-Feng Wu, 2017

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7. Circulating protein biomarker discovery strategies using mass spectrometry for cancer early detection applications [O] . S. Hanash 2015

机译：循环蛋白生物标志物发现策略使用质谱进行癌症早期检测应用

MASS SPECTROMETRY EVALUATION OF CIRCULATING S100A8 AND S100A9 PROTEINS AS PROGNOSIS BIOMARKERS IN SEPSIS

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