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SOLID PHASE MICROEXTRACTION FOR THE QUANTIFICATION OF DOXORUBICIN AND UNTARGETED METABOLIC PROFILING OF LUNG TISSUE DURING IN VIVO LUNG PERFUSION

机译：用于量化多柔比星的定量微萃取，体内肺组织的定量和未明确的肺组织代谢分析

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In vivo lung perfusion is a novel technique designed to localize chemotherapy to the lung tissue suffering metastasis. Effectively, increased doses of chemo agents can be used while reducing systemic exposure to the individual thus decreasing associated side effects (1). As there are currently no techniques available to determine drug tissue concentration during IVLP without taking biopsies, SPME emerged as a feasible strategy for in vivo quantification of doxorubicin (2).

机译：体内肺灌注是一种新颖的技术，旨在将化疗定位到肺组织患有转移。有效地，可以使用增加的化学试剂剂量，同时降低全身暴露于个体，从而降低相关的副作用（1）。由于目前没有可用于确定IVLP的药物组织浓度而不服用活组织检查，因此SPME作为用于多柔比星的体内定量的可行策略（2）。

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《International Mass Spectrometry Conference》|2018年|p1-627|共2页
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Nikita Looby; Barbara Bojko; German Augusto Gomez-Rios; Marcos Tascon; Anna Roszkowska; Krzysztof Gorynski; Janusz Pawliszyn;
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正文语种
中图分类分析化学;
关键词
Chemotherapy; in vivo lung perfusion; human trial; drug monitoring; solid phase microextraction;

机译：化疗;体内肺灌注;人类试验;药物监测;固相微萃取;

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专利

1. Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in?vivo lung chemo-perfusion [J] . Barbara Bojko, Nikita Looby, Mariola Olkowicz, Journal of Pharmaceutical Analysis . 2021,第1期

机译：固相微萃取化学活检工具，用于监测多柔比蛋白残留物在α体内肺部化学灌注
2. Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion [J] . Barbara Bojko, German Gómez-Ríos, Marcos Tascon, 药物分析学报（英文） . 2021,第001期

机译：固相微萃取化学活检工具，用于监测体内肺化学灌注中的多柔比蛋白残留物
3. Ex?Vivo Lung Perfusion Model to Study Pulmonary Tissue Extracellular Microvesicle Profiles [J] . Prashanth Vallabhajosyula, Laxminarayana Korutla, Andreas Habertheuer, The Annals of Thoracic Surgery: Official Journal of the Society of Thoracic Surgeons and the Southern Thoracic Surgical Association . 2017,第6期

机译：Ex？Vivo肺灌注模型用于研究肺组织细胞外微泡的概况
4. SOLID PHASE MICROEXTRACTION FOR THE QUANTIFICATION OF DOXORUBICIN AND UNTARGETED METABOLIC PROFILING OF LUNG TISSUE DURING IN VIVO LUNG PERFUSION [C] . Nikita Looby, Barbara Bojko, German Augusto Gomez-Rios, International Mass Spectrometry Conference . 2018

机译：用于量化多柔比星的定量微萃取，体内肺组织的定量和未明确的肺组织代谢分析
5. Ex-Vivo Lung Perfusion Mediated Delivery of Rituximab to Clear Epstein-Barr Virus in Donor Lungs [D] . Ku, Terrance. 2019

机译：ex-体内肺灌注介导的rituximab递送，以在供体肺中透明epstein-barr病毒
6. Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion [O] . Barbara Bojko, Nikita Looby, Mariola Olkowicz, 2021

机译：固相微萃取化学活检工具用于监测体内肺化学灌注中的多柔比蛋白残留物
7. Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion [O] . Andreasson Anders, Karamanou Danai, Gillespie Colin, 2016

机译：人离体肺灌注过程中灌注液和支气管肺泡灌洗液中的炎症和组织损伤标志物分析

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SOLID PHASE MICROEXTRACTION FOR THE QUANTIFICATION OF DOXORUBICIN AND UNTARGETED METABOLIC PROFILING OF LUNG TISSUE DURING IN VIVO LUNG PERFUSION

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