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CHARACTERISING THE CATABOLISM OF PEPTIDES USING ION MOBILITY ENABLED HIGH RESOLUTION MASS SPECTROMETRY WITH MASS-METASITE INTEGRATION FOR DATA PROCESSING

机译：用离子迁移率表征肽的分解代谢，使高分辨率质谱具有具有质量级乙腈集成的数据处理

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A growing need exists to characterize and optimize the absorption, distribution, metabolism and excretion (ADME) properties of biotherapeutics. The challenge is that few software packages available to characterise the clearance and metabolic fate of biotherapeutics. Here, we mine ion mobility high resolution mass spectrometric data for the analysis of biotherapeutic drug metabolism using the Mass-MetaSite and WebMetabase software platform for processing.

机译：存在不断增长的需要表征和优化生物治疗剂的吸收，分布，代谢和排泄（ADME）性质。挑战是很少有软件包可用于表征BiotheAceutics的间隙和代谢命运。在这里，我们使用质量 - 碳酸盐和WebMetabase软件平台进行生物治疗药代谢的高分辨率高分辨率质谱数据进行分析。

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《International Mass Spectrometry Conference》|2018年|p628-1245|共2页
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Jayne Kirk; Ismeal Zamora; Antoni Riera; Tatiana Radchenko; Anna Escola; Russell Mortishire-Smith; Yun Alelyunas; Mark Wrona;
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正文语种
中图分类分析化学;
关键词
Mass-MetaSite; WebMetabase; IMS QToF; Biotherapeutics; ADME;

机译：群众梅纳斯特;WebMetabase;IMS QTOF;BioTherapeutics;Adme;

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专利

1. Structural Analysis of Neutral Nitrogen Compounds Refractory to the Hydrodenitrogenation Process of Heavy Oil Fractions by High- Resolution Tandem Mass Spectrometry and Ion Mobility-Mass Spectrometry [J] . Le Maitre Johann, Paupy Benoit, Hubert-Roux Marie, Energy & fuels . 2020,第8期

机译：通过高分辨率串联质谱和离子迁移质谱法对重油级分的中性氮化合物的结构分析对重油级分的氢化植入过程
2. A targeted strategy for analyzing untargeted mass spectral data to identify lanostane–type triterpene acids in Poria cocos by integrating a scientific information system and liquid chromatography–tandem mass spectrometry combined with ion mobility spectrometry [J] . Gui–Fang Feng, Yan Zheng, Yufei Sun, Analytica chimica acta . 2018,第期

机译：通过将科学信息系统和液相色谱 - 串联质谱与离子迁移光谱相结合
3. Preprocessing Significantly Improves the Peptide/Protein Identification Sensitivity of High-resolution Isobarically Labeled Tandem Mass Spectrometry Data [J] . Sheng Quanhu, Li Rongxia, Dai Jie, Molecular & cellular proteomics: MCP . 2015,第2期

机译：预处理显着提高了高分辨率等压标记串联质谱数据的肽/蛋白质鉴定灵敏度
4. CHARACTERISING THE CATABOLISM OF PEPTIDES USING ION MOBILITY ENABLED HIGH RESOLUTION MASS SPECTROMETRY WITH MASS-METASITE INTEGRATION FOR DATA PROCESSING [C] . Jayne Kirk, Ismeal Zamora, Antoni Riera, International Mass Spectrometry Conference . 2018

机译：用离子迁移率表征肽的分解代谢，使高分辨率质谱具有具有质量级乙腈集成的数据处理
5. Automated data acquisition and analysis for high-resolution Fourier transform mass spectrometry of proteins and peptides [D] . Robinson, Dana E. 2011

机译：自动数据采集和分析，用于蛋白质和多肽的高分辨率傅里叶变换质谱
6. Preprocessing Significantly Improves the Peptide/Protein Identification Sensitivity of High-resolution Isobarically Labeled Tandem Mass Spectrometry Data [O] . Quanhu Sheng, Rongxia Li, Jie Dai, 2015

机译：预处理显着提高了高分辨率等压标记串联质谱数据的肽/蛋白质鉴定灵敏度
7. Data Collection and Processing Instrumentation for Time-of-Flight Mass Spectrometry and Ion Mobility Time-of-Flight Mass Spectrometry [O] . Sysoev Alexey A., Fomin O.I., Poteshin S.S., 2015

机译：飞行时间质谱和离子迁移飞行时间质谱的数据收集和处理仪器

CHARACTERISING THE CATABOLISM OF PEPTIDES USING ION MOBILITY ENABLED HIGH RESOLUTION MASS SPECTROMETRY WITH MASS-METASITE INTEGRATION FOR DATA PROCESSING

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