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USING MASS SPECTROMETRY TO EXAMINE THE CONFORMATIONAL LANDSCAPE OF PROTEINS - THE PERFECT TOOL TO REPORT ON SELF SOLVATION AND THE EFFECT OF CHARGE LOCATION ON STRUCTURE?

机译：使用质谱法检测蛋白质的构象景观 - 报告自我求解的完美工具及电荷位置对结构的影响？

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Mass spectrometry (MS) coupled with electrospray ionisation (ESI) has been extensively applied to identify proteins and elucidate stoichiometry of protein complexes. Since desolvated species are affected by solvent conditions such as pH, buffer strength and concentration, ESI-MS is an appropriate method by which to consider the range of conformational states that proteins may occupy including natively folded, disordered, denatured and amyloid.

机译：与电喷雾电离（ESI）联接的质谱（MS）已被广泛应用于鉴定蛋白质并阐明蛋白质复合物的化学计量。由于脱溶剂的物种受溶剂条件的影响，例如pH，缓冲强度和浓度，因此ESI-MS是考虑蛋白质可以占据的构象状态的范围，包括本地折叠，无序，变性和淀粉样蛋白。

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来源
《International Mass Spectrometry Conference》|2018年|p1-627|共2页
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作者
Perdita Barran; Dale Stuchfield; Lukasz Migas; Rebecca Beveridge; Jakub Ujma; Bruno Bellina;
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正文语种
中图分类分析化学;
关键词
Variable temperature ion mobility mass spectrometry; disordered proteins;

机译：可变温度离子迁移率质谱;无序蛋白质;

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1. Conformational Characterization and Classification of Intrinsically Disordered Proteins by Native Mass Spectrometry and Charge‐State Distribution Analysis [J] . Santambrogio Carlo, Natalello Antonino, Brocca Stefania, Proteomics . 2019,第6期

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2. Monitoring Conformational Landscape of Ovine Prion Protein Monomer Using Ion Mobility Coupled to Mass Spectrometry [J] . Van der Rest Guillaume, Rezaei Human, Halgand Frederic Journal of the American Society for Mass Spectrometry . 2017,第2期

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3. Mapping Protein Conformational Landscapes under Strongly Native Conditions with Hydrogen Exchange Mass Spectrometry [J] . Witten Jacob, Ruschak Amy, Poterba Timothy, The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2015,第31期

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4. USING MASS SPECTROMETRY TO EXAMINE THE CONFORMATIONAL LANDSCAPE OF PROTEINS - THE PERFECT TOOL TO REPORT ON SELF SOLVATION AND THE EFFECT OF CHARGE LOCATION ON STRUCTURE? [C] . Perdita Barran, Dale Stuchfield, Lukasz Migas, International Mass Spectrometry Conference . 2018

机译：使用质谱法检测蛋白质的构象景观 - 报告自我求解的完美工具及电荷位置对结构的影响？
5. Mass Spectrometry for Determination of Conformation and Dynamics of Proteins and Structure and Biosynthesis of Bacterial Peptidoglycan [D] . Chen, Jiawei 2011

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6. Ion Mobility Spectrometry-Hydrogen Deuterium Exchange Mass Spectrometry of Anions: Part 2. Assessing Charge Site Location and Isotope Scrambling [O] . Mahdiar Khakinejad, Samaneh Ghassabi Kondalaji, Gregory C. Donohoe, -1

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7. Electron transfer with no dissociation ion mobility - mass spectrometry (ETnoD IM-MS) The effect of charge reduction on protein conformation [O] . Jhingree, Jacquelyn, Beveridge, Rebecca, Dickinson, Eleanor, 2017

机译：没有解离离子迁移率的电子转移 - 质谱（ETnoD Im-ms）电荷减少对蛋白质构象的影响

USING MASS SPECTROMETRY TO EXAMINE THE CONFORMATIONAL LANDSCAPE OF PROTEINS - THE PERFECT TOOL TO REPORT ON SELF SOLVATION AND THE EFFECT OF CHARGE LOCATION ON STRUCTURE?

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