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Optimization of Reductive Alkylation Catalysts by Experimental Design

机译：实验设计优化还原烷基化催化剂

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Reductive alkylation is an efficient method to synthesize secondary amines from primary amines. The aim of this study is to optimize sulfur-promoted platinum catalysts for the reductive alkylation of p-aminodiphenylamine (ADPA) with methyl isobutyl ketone (MIBK) to improve the productivity of N-(l,3-dimethylbutyl)-N-phenyl-p-phenylenediamine (6-PPD). In this study, we focus on Pt loading, the amount of sulfur, and the pH as the variables. The reaction was conducted in the liquid phase under kinetically limited conditions in a continuously stirred tank reactor at a constant hydrogen pressure. Use of the two-factorial design minimized the number of experiments needed to arrive at the optimal solution. The activity and selectivity of the reaction was followed using the hydrogen-uptake and chromatographic analysis of products. The most optimal catalyst was identified to be l%Pt-0.1%S/C prepared at a pH of 6.
机译：还原烷基化是合成原发性胺的二次胺的有效方法。本研究的目的是优化硫促进的铂催化剂，用于将对氨基二苯胺（ADPA）的甲基异丁基酮（MIBK）的还原烷基化烷基化，以改善N-（L，3-二甲基丁基）-N-苯基 - 对苯二胺（6-PPD）。在这项研究中，我们专注于Pt加载，硫的量，以及pH作为变量。在恒定的氢气压力下在连续搅拌的罐反应器中在液相中在液相中在液相中进行反应。使用两个因子设计最小化了到达最佳解决方案所需的实验数量。使用产物的氢吸收和色谱分析，然后使用产物的活性和选择性。将最佳催化剂鉴定为在pH的pH下制备的L％Pt-0.1％S / C.

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