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首页> 外文会议>European Meeting on Supercritical Fluids >RE-CRYSTALLIZATION AND MICRONIZATION OF A PHARMACEUTICAL COMPOUND OF ANTIPYRINE BY APPLYING THE SUPERCRITICAL FLUID TECHNOLOGY
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RE-CRYSTALLIZATION AND MICRONIZATION OF A PHARMACEUTICAL COMPOUND OF ANTIPYRINE BY APPLYING THE SUPERCRITICAL FLUID TECHNOLOGY

机译：通过施加超临界流体技术重结晶和微粉化反丝氨酸的药物化合物

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This study presents the experimental results for the micronization of an API of antipyrine using the rapid expansion of supercritical solution (RESS) process. The high pressure experimental system included three sections of carbon dioxide delivery, extraction of antipyrine, and the precipitator. Particle morphology and crystallinity were examined by SEM and XRD, respectively. Particle size and its distributions were determined using image analysis software Image-J. The optimal operating conditions of extraction, pre-expansion and post-expansion temperatures were determined. The mean particle size was reduced to one tenth of its original value after the optimal RESS process. The dissolution rate of the micronized antipyrine was enhanced by 20% in a simulated intestinal buffer solution.
机译：本研究介绍了使用超临界溶液（RESS）工艺的快速膨胀的反滤液微粉化的实验结果。高压实验系统包括三个二氧化碳递送，萃取反紫红色和除尘器。通过SEM和XRD检查颗粒形态和结晶度。使用图像分析软件图像-J确定粒度及其分布。确定了提取，预膨胀和后膨胀温度的最佳操作条件。在最佳RESS过程之后，平均粒度将其原始值的1分之一。在模拟肠缓冲溶液中，将微粉化反丝氨酸的溶出速率提高了20％。

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